O1-(DIMETHOXYTRITYL)PROPANE-1,3-DIOL

Base Information

• Chemical Name: O1-(DIMETHOXYTRITYL)PROPANE-1,3-DIOL
• CAS No.: 110675-04-2
• Molecular Formula: C24H26O4
• Molecular Weight: 378.46100
• Mol file: 110675-04-2.mol

Synonyms:

Chemical Property of O1-(DIMETHOXYTRITYL)PROPANE-1,3-DIOL

Chemical Property:

• Boiling Point: 533.8±50.0 °C(Predicted)
• PKA: 14.84±0.10(Predicted)
• PSA: 47.92000
• Density: 1.132±0.06 g/cm3(Predicted)
• LogP: 4.39470

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of O1-(DIMETHOXYTRITYL)PROPANE-1,3-DIOL

There total 2 articles about O1-(DIMETHOXYTRITYL)PROPANE-1,3-DIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + trimethyleneglycol (504-63-2) → 3<(4,4'-dimethoxytrityl)oxy>propan-1-ol (110675-04-2)

Guidance literature:

With pyridine; at 20 ℃; for 26h;

DOI:10.1002/anie.201900993

Reference yield: 62.0%

→ 3<(4,4'-dimethoxytrityl)oxy>propan-1-ol (110675-04-2)

Guidance literature:

With pyridine;

Reference yield: 75.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + 3<(4,4'-dimethoxytrityl)oxy>propan-1-ol (110675-04-2) → 3-(4,4'-dimethoxytriphenylmethyloxy)-propyl 2-cyanoethyl N,N-diisopropylphosphoramidite (110894-23-0)

Guidance literature:

With N,N-dimethyl-ethanamine; In dichloromethane; at 20 ℃; for 0.666667h; Inert atmosphere;

DOI:10.1039/c4cc04719b

upstream raw materials:

4,4'-dimethoxytrityl chloride

trimethyleneglycol

Downstream raw materials:

C₂₉H₃₄NO₅P

3-(4,4'-dimethoxytriphenylmethyloxy)-propyl 2-cyanoethyl N,N-diisopropylphosphoramidite

C₂₄H₂₄O₄

Refernces

• 1、 Shu, Zhaoma,Tanaka, Iku,Ota, Azumi,Fushihara, Daichi,Abe, Naoko,Kawaguchi, Saki,Nakamoto, Kosuke,Tomoike, Fumiaki,Tada, Seiichi,Ito, Yoshihiro,Kimura, Yasuaki,Abe, Hiroshi. "Disulfide-Unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA". . p. 6611 - 6615. Retrieved 2019.
• 2、 Wawrzyniak-Turek, Katarzyna,H?bartner, Claudia. "Enzymatic combinatorial nucleoside deletion scanning mutagenesis of functional RNA". . p. 10937 - 10940. Retrieved 2014.
• 3、 -. "RNA interference agent, method for producing same, and use therefor". Page/Page column 14; 15. . Retrieved 2018/07/15.