3-(2-Chloro-phenyl)-2-mercapto-3H-quinazolin-4-one

Base Information

• Chemical Name: 3-(2-Chloro-phenyl)-2-mercapto-3H-quinazolin-4-one
• CAS No.: 65141-60-8
• Molecular Formula: C14H9ClN2OS
• Molecular Weight: 288.757
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40366379
• Wikidata: Q82151564

Synonyms:65141-60-8;3-(2-Chloro-phenyl)-2-mercapto-3H-quinazolin-4-one;3-(2-chlorophenyl)-2-mercaptoquinazolin-4(3H)-one;3-(2-chlorophenyl)-2-sulfanylidene-1H-quinazolin-4-one;3-(2-chlorophenyl)-2-sulfanyl-3,4-dihydroquinazolin-4-one;3-(2-chlorophenyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one;SCHEMBL5028796;DTXSID40366379;MFCD01995808;STK414889;STL135930;AKOS000116384;AKOS005746172;CCG-313562;LS-08426;CS-0349071;EN300-03307;3-(2-chlorophenyl)-2-mercapto-3h-quinazolin-4-one;3-(2-Chlorophenyl)-2-mercapto-4(3H)-quinazolinone;3-(2-chlorophenyl)-2-sulfanylquinazolin-4(3H)-one;Z55663914;3-(2-chlorophenyl)-2-thioxo-2,3-dihydro benzopyrimidin-4-one;3-(2-Chlorophenyl)-2-sulfanylidene-2,3-dihydroquinazolin-4(1H)-one

Chemical Property of 3-(2-Chloro-phenyl)-2-mercapto-3H-quinazolin-4-one

Chemical Property:

• Vapor Pressure: 6.23E-08mmHg at 25°C
• Refractive Index: 1.753
• Boiling Point: 439.7 °C at 760 mmHg
• Flash Point: 219.7 °C
• PSA: 73.69000
• Density: 1.5 g/cm³
• LogP: 3.32780
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 288.0124118
• Heavy Atom Count: 19
• Complexity: 390

Purity/Quality:

99% ^*data from raw suppliers

3-(2-Chlorophenyl)-2-mercaptoquinazolin-4(3H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=O)N(C(=S)N2)C3=CC=CC=C3Cl

Technology Process of 3-(2-Chloro-phenyl)-2-mercapto-3H-quinazolin-4-one

There total 10 articles about 3-(2-Chloro-phenyl)-2-mercapto-3H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-chlorophenylisothiocyanate (2740-81-0) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 3‐(2‐chlorophenyl)‐2‐thioxo‐2,3‐dihydroquinazolin‐4(1H)‐one (65141-60-8)

Guidance literature:

With triethylamine; In ethanol; for 3h; Reflux;

DOI:10.1002/chem.201905219

Reference yield: 85.0%

N-(2-chlorophenyl)-methyl dithiocarbamic acid (13037-24-6) + 2-carbomethoxyaniline (134-20-3) → 3‐(2‐chlorophenyl)‐2‐thioxo‐2,3‐dihydroquinazolin‐4(1H)‐one (65141-60-8)

Guidance literature:

With potassium carbonate; In ethanol; for 25h; Reflux;

DOI:10.1007/s11094-021-02371-7

Reference yield: 69.0%

2-bromobenzoic acid methyl ester (610-94-6) + 2-chlorophenylisothiocyanate (2740-81-0) → 3‐(2‐chlorophenyl)‐2‐thioxo‐2,3‐dihydroquinazolin‐4(1H)‐one (65141-60-8)

Guidance literature:

2-bromobenzoic acid methyl ester; With sodium azide; potassium carbonate; L-proline; copper(I) bromide; In dimethyl sulfoxide; at 85 ℃; for 3h;

2-chlorophenylisothiocyanate; In dimethyl sulfoxide; at 85 ℃; for 4h;

DOI:10.1002/aoc.4635

upstream raw materials:

2-chlorophenylisothiocyanate

anthranilic acid

N-(2-chlorophenyl)-methyl dithiocarbamic acid

o-chloroaniline

Downstream raw materials:

C₂₀H₁₉ClN₂O₃S

3-Amino-2-(2-chloro-phenylamino)-3H-quinazolin-4-one

2,2'-dithiobis<3-(2-chlorophenyl)-4(3H)-quinazolinone>

3-(2-chloro-phenyl)-2-ethylsulfanyl-3H-quinazolin-4-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 65141-60-8 3-(2-CHLORO-PHENYL)-2-MERCAPTO-3H-QUINAZOLIN-4-ONE

Send

Send

Metric Ton KG G Pound L ML

Send

Send