3-Quinolinecarboxylic acid, 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-5-[(phenylmethyl)amino]- , ethyl ester

Base Information

Chemical Name:3-Quinolinecarboxylic acid, 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-5-[(phenylmethyl)amino]- , ethyl ester
CAS No.:110872-04-3
Molecular Formula:C22H19F3N2O3
Molecular Weight:416.4
Hs Code.:
Mol file:110872-04-3.mol

Synonyms:Ethyl 5-benzylamino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate;.ethyl 5-benzylamino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-5-[(phenylmethyl)amino]- , ethyl ester

Chemical Property:

PSA：60.33000
LogP:4.61550

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-5-[(phenylmethyl)amino]- , ethyl ester

There total 6 articles about 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-5-[(phenylmethyl)amino]- , ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 107564-02-3
1-cyclopropyl-5,6,7,8-tetrafluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid,ethyl ester

: 100-46-9
benzylamine

: 110872-04-3
ethyl 5-(benzylamino)-1-cyclopropyl-6,7,8-trifluoro-4(1H)-oxoquinoline-3-carboxylate

Guidance literature:: In toluene; at 90 ℃; for 2h;

Reference yield:

pentafluorobenzoylchloride: 2251-50-5
pentafluorobenzoylchloride

: 110872-04-3
ethyl 5-(benzylamino)-1-cyclopropyl-6,7,8-trifluoro-4(1H)-oxoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -10 - 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: 2.5 h / 145 °C / Inert atmosphere

3.1: methanol / 1 h / 0 - 28 °C

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

5.1: triethylamine / toluene / 4 h / 100 °C

With n-butyllithium; sodium hydride; triethylamine; In tetrahydrofuran; methanol; toluene;

Reference yield:

: 3516-87-8
ethyl 2,3,4,5,6-pentafluorobenzoylacetate

: 110872-04-3
ethyl 5-(benzylamino)-1-cyclopropyl-6,7,8-trifluoro-4(1H)-oxoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 2.5 h / 145 °C / Inert atmosphere

2: methanol / 1 h / 0 - 28 °C

3: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

4: triethylamine / toluene / 4 h / 100 °C

With sodium hydride; triethylamine; In tetrahydrofuran; methanol; toluene;