Ethyl 2,2-bis(benzyloxy)propanoate

Base Information

• Chemical Name: Ethyl 2,2-bis(benzyloxy)propanoate
• CAS No.: 110995-43-2
• Molecular Formula: C19H22O4
• Molecular Weight: 314.381
• DSSTox Substance ID: DTXSID50559038
• Wikidata: Q82441558
• Mol file: 110995-43-2.mol

Synonyms:110995-43-2;Ethyl 2,2-bis(benzyloxy)propanoate;DTXSID50559038

Chemical Property of Ethyl 2,2-bis(benzyloxy)propanoate

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 314.15180918
• Heavy Atom Count: 23
• Complexity: 321

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(C)(OCC1=CC=CC=C1)OCC2=CC=CC=C2

Technology Process of Ethyl 2,2-bis(benzyloxy)propanoate

There total 1 articles about Ethyl 2,2-bis(benzyloxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl 2,2-diethoxypropionate (7476-20-2) + benzyl alcohol (100-51-6,185532-71-2) → 2,2-Bis(benzyloxy)propionsaeure-ethylester (110995-43-2)

Guidance literature:

With potassium hydrogencarbonate; for 10h; Heating;

DOI:10.1002/hlca.19890720205

Reference yield: 86.0%

2,2-Bis(benzyloxy)propionsaeure-ethylester (110995-43-2) → ethyl 2-(benzyloxy)acrylate (110995-44-3)

Guidance literature:

With phosphorus pentoxide; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

DOI:10.1002/hlca.19890720205

Reference yield:

2,2-Bis(benzyloxy)propionsaeure-ethylester (110995-43-2) → (Z)-2-(benzyloxy)-N-methyl-3-(phenylthio)acrylamide (90461-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) P₄O₁₀, 2) F^- / 1) DMF, 100 deg C, 2) THF

2: 1) N-chlorosuccinimide, NEt₃ / 1) CCl₄

With N-chloro-succinimide; phosphorus pentoxide; fluoride; triethylamine;

upstream raw materials:

ethyl 2,2-diethoxypropionate

benzyl alcohol

Downstream raw materials:

ethyl 2-(benzyloxy)acrylate

2-Benzyloxy-3-(phenylthio)-propionsaeure-ethylester

(Z)-2-(benzyloxy)-N-methyl-3-(phenylthio)acrylamide

2-O-benzyl-3-deoxy-5,6:7,8-di-O-isopropylidene-3-(phenylthio)-D-manno-oct-2-enono-1,4-lactone