7476-20-2Relevant articles and documents
Pyrimidopyrimidine compounds
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, (2008/06/13)
A range of dipyridamole analogues useful for inhibiting transport of nucleosides or purines across cell membranes, thereby to potentiate the activity of various cytotoxic antitumor drugs, is disclosed. These analogues comprise compounds having general structural formula (I) or pharmaceutically acceptable salts thereof; wherein R1is chloro and R3is diethanolamino, or R1and R3are identical and are selected from allyl, halo, diethanolamino, solketalo and a group having the formula: —O—Rzor —NHRz, Rzbeing selected from alkyl, hydroxyalkyl, alkoxyalkyl, dialkoxyalkyl and 2-oxo-alkyl wherein the or each alkyl and/or alkoxy moiety has less than six carbon atoms, and R2and R4are identical and are selected from piperidino, N-tetrahydroisoquinolyl, and a benzylamino group having structural formula (II) wherein R5is H, or an optionally substituted alkyl or benzyl group, and R6and R7represent H or optional substituents in the aromatic nucleus selected from halo, alkyl, alkoxy, hydroxy, trifluoromethyl, azido, cyano, nitro, carboxyl, carboxylic ester, amino or a substituted amino NRxRywhere Rxand Ryeach represent hydrogen or alkyl, subject to the provisos that (a) if R1and R3are both chloro or diethanolamino, R2and R4are not both benzylamino, i.e. R2and R4do not correspond to structure II with R5, R6and R7each being hydrogen, and (b) if R2and R4are both piperidino, R1and R3are not both chloro, diethanolamino, solketalo or (2,3-dimethoxy)propoxy
