Technology Process of L-Tyrosine,
O-[3-[4-(acetyloxy)butyl]-4-methoxyphenyl]-3,5-diiodo-N-(trifluoroacetyl)-
, ethyl ester
There total 8 articles about L-Tyrosine,
O-[3-[4-(acetyloxy)butyl]-4-methoxyphenyl]-3,5-diiodo-N-(trifluoroacetyl)-
, ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 56 percent / dicyclohexylamino-18-crown-6, KOBu-t / CH2Cl2 / Ambient temperature
2: 63 percent / H2 / Pd/C / ethanol / 10 °C / 2068.6 Torr
3: 1.) CH3SO2Cl / 1.) pyridine, reflux, 10 min, 2.) reflux, 1 h
4: H2 / Pd/C / acetic acid
5: 1.) NaNO2, H2SO4, 2.) I2, KI / 1.) H2O, -7 deg C, 2.) CHCl3, 1.5 h
With
perhydrodibenzo-18-crown-6; sulfuric acid; potassium tert-butylate; hydrogen; iodine; methanesulfonyl chloride; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00396a008
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 97 percent / adogen 464, NaOH / CH2Cl2; H2O / 2 h
2: 56 percent / dicyclohexylamino-18-crown-6, KOBu-t / CH2Cl2 / Ambient temperature
3: 63 percent / H2 / Pd/C / ethanol / 10 °C / 2068.6 Torr
4: 1.) CH3SO2Cl / 1.) pyridine, reflux, 10 min, 2.) reflux, 1 h
5: H2 / Pd/C / acetic acid
6: 1.) NaNO2, H2SO4, 2.) I2, KI / 1.) H2O, -7 deg C, 2.) CHCl3, 1.5 h
With
perhydrodibenzo-18-crown-6; sodium hydroxide; adogen 464; sulfuric acid; potassium tert-butylate; hydrogen; iodine; methanesulfonyl chloride; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
ethanol; dichloromethane; water; acetic acid;
DOI:10.1021/jm00396a008
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 56 percent / dicyclohexylamino-18-crown-6, KOBu-t / CH2Cl2 / Ambient temperature
2: 63 percent / H2 / Pd/C / ethanol / 10 °C / 2068.6 Torr
3: 1.) CH3SO2Cl / 1.) pyridine, reflux, 10 min, 2.) reflux, 1 h
4: H2 / Pd/C / acetic acid
5: 1.) NaNO2, H2SO4, 2.) I2, KI / 1.) H2O, -7 deg C, 2.) CHCl3, 1.5 h
With
perhydrodibenzo-18-crown-6; sulfuric acid; potassium tert-butylate; hydrogen; iodine; methanesulfonyl chloride; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00396a008