5-Hydroxy-2-methoxybenzaldehyde

Base Information

• Chemical Name: 5-Hydroxy-2-methoxybenzaldehyde
• CAS No.: 35431-26-6
• Molecular Formula: C8H8O3
• Molecular Weight: 152.15
• Hs Code.: 2912499000
• Mol file: 35431-26-6.mol

Synonyms:5-Hydroxy-2-methoxybenzaldehyde;2-Methoxy-5-hydroxybenzaldehyde

Chemical Property of 5-Hydroxy-2-methoxybenzaldehyde

Chemical Property:

• Vapor Pressure: 0.000361mmHg at 25°C
• Melting Point: 110-115 °C
• Boiling Point: 309°C at 760 mmHg
• PKA: 9.73±0.18(Predicted)
• Flash Point: 130.4°C
• PSA: 46.53000
• Density: 1.231g/cm³
• LogP: 1.21330
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Acetone (Slightly), DMSO (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

5-Hydroxy-2-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Hydroxy-2-methoxybenzaldehyde

There total 14 articles about 5-Hydroxy-2-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methoxy-5-(methoxycarbonyloxy)benzaldehyde (132638-49-4) → 5-hydroxy-2-methoxybenzaldehyde (35431-26-6)

Guidance literature:

With hydrogenchloride; In methanol; for 5h; Heating;

Reference yield: 88.0%

5-bromo-2-methoxybenzaldehyde (25016-01-7) → 5-hydroxy-2-methoxybenzaldehyde (35431-26-6)

Guidance literature:

With 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; at 80 ℃; for 18h;

DOI:10.1021/ja0639719

Reference yield: 84.0%

C10H10O4 → 5-hydroxy-2-methoxybenzaldehyde (35431-26-6)

Guidance literature:

With methanol; potassium permanganate; trimethylsulphonium iodide; at 25 ℃; under 760.051 Torr; chemoselective reaction;

DOI:10.1039/d1ra03209g

upstream raw materials:

2-methoxy-5-(methoxycarbonyloxy)benzaldehyde

ortho-anisaldehyde

5-bromo-2-methoxybenzaldehyde

methyl 4-methoxyphenyl carbonate

Downstream raw materials:

5-(benzyloxy)-2-methoxybenzaldehyde

4-bromo-5-hydroxy-2-methoxybenzaldehyde

2-methoxy-5-(methoxymethoxy)benzaldehyde

C₁₁H₁₂O₄

Refernces

• 1、 Gurawa, Aakanksha,Kashyap, Sudhir,Kumar, Manoj. "Me3SI-promoted chemoselective deacetylation: a general and mild protocol". . p. 19310 - 19315. Retrieved 2021/06/03.
• 2、 Sang, Ruocheng,Korkis, Stamatis E.,Su, Wanqi,Ye, Fei,Engl, Pascal S.,Berger, Florian,Ritter, Tobias. "Site-Selective C?H Oxygenation via Aryl Sulfonium Salts". . p. 16161 - 16166. Retrieved 2019/11/03.