L-Tyrosine, 3,5-diiodo-O-[3-(4-methoxy-1-butenyl)-4-[(phenylsulfonyl)oxy]phenyl]-N-( trifluoroacetyl)-, methyl ester, (Z)-

Base Information

Chemical Name:L-Tyrosine, 3,5-diiodo-O-[3-(4-methoxy-1-butenyl)-4-[(phenylsulfonyl)oxy]phenyl]-N-( trifluoroacetyl)-, methyl ester, (Z)-
CAS No.:111088-67-6
Molecular Formula:C₂₉H₂₆F₃I₂NO₈S
Molecular Weight:859.398
Hs Code.:
Mol file:111088-67-6.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Tyrosine, 3,5-diiodo-O-[3-(4-methoxy-1-butenyl)-4-[(phenylsulfonyl)oxy]phenyl]-N-( trifluoroacetyl)-, methyl ester, (Z)-

Chemical Property:

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Technology Process of L-Tyrosine, 3,5-diiodo-O-[3-(4-methoxy-1-butenyl)-4-[(phenylsulfonyl)oxy]phenyl]-N-( trifluoroacetyl)-, methyl ester, (Z)-

There total 5 articles about L-Tyrosine, 3,5-diiodo-O-[3-(4-methoxy-1-butenyl)-4-[(phenylsulfonyl)oxy]phenyl]-N-( trifluoroacetyl)-, methyl ester, (Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19231-06-2
4,4'-dimethoxy-diphenyliodonium bromide

: 111088-67-6
(S)-3-{4-[4-Benzenesulfonyloxy-3-((Z)-4-methoxy-but-1-enyl)-phenoxy]-3,5-diiodo-phenyl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 46 percent / Cu, Et₃N / methanol

2: 79 percent / SnCl₄ / CH₂Cl₂ / 4 h / 0 °C

3: 74 percent / pyridine / 3 h

4: dicyclohexano-18-crown-6, KOBu-t / CH₂Cl₂ / 5 h

With pyridine; perhydrodibenzo-18-crown-6; potassium tert-butylate; tin(IV) chloride; copper; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm00396a008

Reference yield:

: 100-66-3
methoxybenzene

: 111088-67-6
(S)-3-{4-[4-Benzenesulfonyloxy-3-((Z)-4-methoxy-but-1-enyl)-phenoxy]-3,5-diiodo-phenyl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: iodine tris(trifluoroacetate)

2: 46 percent / Cu, Et₃N / methanol

3: 79 percent / SnCl₄ / CH₂Cl₂ / 4 h / 0 °C

4: 74 percent / pyridine / 3 h

5: dicyclohexano-18-crown-6, KOBu-t / CH₂Cl₂ / 5 h

With pyridine; perhydrodibenzo-18-crown-6; iodine tris(trifluoroacetate); potassium tert-butylate; tin(IV) chloride; copper; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm00396a008

Reference yield:

: 111088-56-3
3,5-diiodo-O-methyl-N-(trifluoroacetyl)-L-thyronine methyl ester

: 111088-67-6
(S)-3-{4-[4-Benzenesulfonyloxy-3-((Z)-4-methoxy-but-1-enyl)-phenoxy]-3,5-diiodo-phenyl}-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / SnCl₄ / CH₂Cl₂ / 4 h / 0 °C

2: 74 percent / pyridine / 3 h

3: dicyclohexano-18-crown-6, KOBu-t / CH₂Cl₂ / 5 h

With pyridine; perhydrodibenzo-18-crown-6; potassium tert-butylate; tin(IV) chloride; In dichloromethane;
DOI:10.1021/jm00396a008