(E)-3'-Hydroxy-3,5,4'-trimethoxystilbene

Base Information

• Chemical Name: (E)-3'-Hydroxy-3,5,4'-trimethoxystilbene
• CAS No.: 108957-73-9
• Molecular Formula: C17H18 O4
• Molecular Weight: 286.328
• Hs Code.: 2909500000
• NSC Number: 381864
• UNII: KPM93CW8F2
• Nikkaji Number: J1.237.408I
• Metabolomics Workbench ID: 133878
• ChEMBL ID: CHEMBL419378
• Mol file: 108957-73-9.mol

Synonyms:4,3',5'-tri-O-methylpiceatannol;NSC 381864;NSC-381864

Chemical Property of (E)-3'-Hydroxy-3,5,4'-trimethoxystilbene

Chemical Property:

• Appearance/Colour: off-white crystalline powder
• Melting Point: 89 ～ 91 ºC
• PSA: 47.92000
• LogP: 3.58840
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 286.12050905
• Heavy Atom Count: 21
• Complexity: 319

Purity/Quality:

97% ^*data from raw suppliers

(E) -3'-HYDROXY-3,5,4'-TRIMETHOXYSTILBENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C=CC2=CC(=CC(=C2)OC)OC)O
• Isomeric SMILES: COC1=C(C=C(C=C1)/C=C/C2=CC(=CC(=C2)OC)OC)O

Technology Process of (E)-3'-Hydroxy-3,5,4'-trimethoxystilbene

There total 14 articles about (E)-3'-Hydroxy-3,5,4'-trimethoxystilbene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

trans-3,4',5-trimethoxy-3'-tert-butyldimethylsilyloxystilbene (586410-27-7) → NSC381864 (108957-73-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2006.08.088

Reference yield: 85.0%

1,3-dimethoxy-5-[(E)-3-acetoxy-4-methoxystyryl]benzene (108957-76-2) → NSC381864 (108957-73-9)

Guidance literature:

With methanol; sodium methylate; for 3h; Reflux;

Reference yield: 81.0%

(2S,3R,4S,5R,6R)-2-{5-[(E)-2-(3,5-Dimethoxy-phenyl)-vinyl]-2-methoxy-phenoxy}-3,4,5-trimethoxy-6-methoxymethyl-tetrahydro-pyran → NSC381864 (108957-73-9)

Guidance literature:

With hydrogenchloride; In methanol; for 2h; Heating;

DOI:10.1016/S0968-0896(00)00215-7

upstream raw materials:

methanol

(2S,3R,4S,5R,6R)-2-{3-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-5-methoxy-phenoxy}-3,4,5-trimethoxy-6-methoxymethyl-tetrahydro-pyran

trans-3,4',5-trimethoxy-3'-tert-butyldimethylsilyloxystilbene

isovanillin

Downstream raw materials:

1,3-dimethoxy-5-[(E)-3-acetoxy-4-methoxystyryl]benzene

(E)-tetramethylpiceatannol

trans-piceatannol