Guanosine, N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-3'-O-[tris(1-methyleth yl)silyl]-, 2'-(hydrogen butanedioate)

Base Information

• Chemical Name: Guanosine, N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-3'-O-[tris(1-methyleth yl)silyl]-, 2'-(hydrogen butanedioate)
• CAS No.: 111160-35-1
• Molecular Formula: C50H57N5O10Si
• Molecular Weight: 916.116
• Mol file: 111160-35-1.mol

Synonyms:

Chemical Property of Guanosine, N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-3'-O-[tris(1-methyleth yl)silyl]-, 2'-(hydrogen butanedioate)

Chemical Property:

Purity/Quality:

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Technology Process of Guanosine, N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-3'-O-[tris(1-methyleth yl)silyl]-, 2'-(hydrogen butanedioate)

There total 3 articles about Guanosine, N-benzoyl-5'-O-[(4-methoxyphenyl)diphenylmethyl]-3'-O-[tris(1-methyleth yl)silyl]-, 2'-(hydrogen butanedioate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N2-benzoyl-5'-O-(monomethoxytrityl)guanosine (70689-35-9) → N2-benzoyl-5'-O-(monomethoxytrityl)-3'-O-(ttriisopropylsilyl)guanosine 2'-O-succinate (111160-35-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 25 percent / imidazole / dimethylformamide

2: DMAP, pyridine / 72 h / Ambient temperature

With pyridine; 1H-imidazole; dmap; In N,N-dimethyl-formamide;

DOI:10.1021/ja00259a037

Reference yield:

triisopropylsilyl chloride (13154-24-0) → N2-benzoyl-5'-O-(monomethoxytrityl)-3'-O-(ttriisopropylsilyl)guanosine 2'-O-succinate (111160-35-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 25 percent / imidazole / dimethylformamide

2: DMAP, pyridine / 72 h / Ambient temperature

With pyridine; 1H-imidazole; dmap; In N,N-dimethyl-formamide;

DOI:10.1021/ja00259a037

Reference yield:

succinic acid anhydride (108-30-5) + N-(9-{(2R,3R,4S,5R)-3-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-4-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-benzamide (111266-84-3) → N2-benzoyl-5'-O-(monomethoxytrityl)-3'-O-(ttriisopropylsilyl)guanosine 2'-O-succinate (111160-35-1)

Guidance literature:

With pyridine; dmap; for 72h; Yield given; Ambient temperature;

DOI:10.1021/ja00259a037

upstream raw materials:

succinic acid anhydride

N-(9-{(2R,3R,4S,5R)-3-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-4-triisopropylsilanyloxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-benzamide

N²-benzoyl-5'-O-(monomethoxytrityl)guanosine

triisopropylsilyl chloride

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