Benzeneacetic acid, 4-methoxy-a-(1-methylethyl)-, 3-hydroxy-2,2-dimethylpropyl ester, (S)-

Base Information

Chemical Name:Benzeneacetic acid, 4-methoxy-a-(1-methylethyl)-, 3-hydroxy-2,2-dimethylpropyl ester, (S)-
CAS No.:111197-99-0
Molecular Formula:C17H26O4
Molecular Weight:294.391
Hs Code.:

Synonyms:

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Chemical Property of Benzeneacetic acid, 4-methoxy-a-(1-methylethyl)-, 3-hydroxy-2,2-dimethylpropyl ester, (S)-

Chemical Property:

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Technology Process of Benzeneacetic acid, 4-methoxy-a-(1-methylethyl)-, 3-hydroxy-2,2-dimethylpropyl ester, (S)-

There total 9 articles about Benzeneacetic acid, 4-methoxy-a-(1-methylethyl)-, 3-hydroxy-2,2-dimethylpropyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 111197-91-2
(S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone 2,2-dimethyl-trimethylene acetal

: 111197-99-0
3-hydroxy-2,2-dimethylpropyl (S)-2-(4-methoxyphenyl)-3-methylbutanoate

Guidance literature:: With water; sodium acetate; In methanol; at 100 - 110 ℃; in closed pressure bottle;
DOI:10.1246/bcsj.60.1027

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 111197-99-0
3-hydroxy-2,2-dimethylpropyl (S)-2-(4-methoxyphenyl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 9 steps

1: 99 percent / sodium nitrite, 2M H₂SO₄ / H₂O

2: 81 percent / diethyl ether / ice cooling

3: 80 percent / 4-dimethylaminopyridine / 110 h / 70 °C

4: 88 percent / PPTS / CH₂Cl₂ / from 0 deg C to rt

5: 85 percent / tetrahydrofuran / 1 h / ice cooling

6: 97 percent / PPTS / ethanol / 6 h

7: 57 percent / p-toluenesulfonoc acid / benzene / 50 °C

8: 94 percent / pyridine / 12 h / Ambient temperature

9: 96 percent / sodium acetate, water / methanol / 100 - 110 °C / in closed pressure bottle

With pyridine; dmap; sulfuric acid; water; sodium acetate; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; sodium nitrite; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; benzene;
DOI:10.1246/bcsj.60.1027

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 111197-99-0
3-hydroxy-2,2-dimethylpropyl (S)-2-(4-methoxyphenyl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 81 percent / diethyl ether / ice cooling

2: 80 percent / 4-dimethylaminopyridine / 110 h / 70 °C

3: 88 percent / PPTS / CH₂Cl₂ / from 0 deg C to rt

4: 85 percent / tetrahydrofuran / 1 h / ice cooling

5: 97 percent / PPTS / ethanol / 6 h

6: 57 percent / p-toluenesulfonoc acid / benzene / 50 °C

7: 94 percent / pyridine / 12 h / Ambient temperature

8: 96 percent / sodium acetate, water / methanol / 100 - 110 °C / in closed pressure bottle

With pyridine; dmap; water; sodium acetate; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; benzene;
DOI:10.1246/bcsj.60.1027