(S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone 2,2-dimethyl-trimethylene acetal

Base Information

Chemical Name:(S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone 2,2-dimethyl-trimethylene acetal
CAS No.:111197-91-2
Molecular Formula:C₁₈H₂₈O₆S
Molecular Weight:372.483
Hs Code.:

Synonyms:(S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone 2,2-dimethyl-trimethylene acetal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone 2,2-dimethyl-trimethylene acetal

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Technology Process of (S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone 2,2-dimethyl-trimethylene acetal

There total 8 articles about (S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone 2,2-dimethyl-trimethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 124-63-0
methanesulfonyl chloride

: 111460-87-8
(S)-2-hydroxy-1-(4-methoxyphenyl)-3-methyl-1-propanone 2,2-dimethyl-trimethylene acetal

: 111197-91-2
(S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone 2,2-dimethyl-trimethylene acetal

Guidance literature:: With pyridine; for 12h; Ambient temperature;
DOI:10.1246/bcsj.60.1027

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 111197-91-2
(S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone 2,2-dimethyl-trimethylene acetal

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / sodium nitrite, 2M H₂SO₄ / H₂O

2: 81 percent / diethyl ether / ice cooling

3: 80 percent / 4-dimethylaminopyridine / 110 h / 70 °C

4: 88 percent / PPTS / CH₂Cl₂ / from 0 deg C to rt

5: 85 percent / tetrahydrofuran / 1 h / ice cooling

6: 97 percent / PPTS / ethanol / 6 h

7: 57 percent / p-toluenesulfonoc acid / benzene / 50 °C

8: 94 percent / pyridine / 12 h / Ambient temperature

With pyridine; dmap; sulfuric acid; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; sodium nitrite; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; benzene;
DOI:10.1246/bcsj.60.1027

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 111197-91-2
(S)-2-methylsulfonyloxy-1-(4-methoxyphenyl)-3-methyl-1-butanone 2,2-dimethyl-trimethylene acetal

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / diethyl ether / ice cooling

2: 80 percent / 4-dimethylaminopyridine / 110 h / 70 °C

3: 88 percent / PPTS / CH₂Cl₂ / from 0 deg C to rt

4: 85 percent / tetrahydrofuran / 1 h / ice cooling

5: 97 percent / PPTS / ethanol / 6 h

6: 57 percent / p-toluenesulfonoc acid / benzene / 50 °C

7: 94 percent / pyridine / 12 h / Ambient temperature

With pyridine; dmap; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; benzene;
DOI:10.1246/bcsj.60.1027