6-(1H-iMidazol-1-yl)nicotinaldehyde

Base Information

• Chemical Name: 6-(1H-iMidazol-1-yl)nicotinaldehyde
• CAS No.: 111205-03-9
• Molecular Formula: C9H7N3O
• Molecular Weight: 0.00000
• Mol file: 111205-03-9.mol

Synonyms:

Chemical Property of 6-(1H-iMidazol-1-yl)nicotinaldehyde

Chemical Property:

• Melting Point: 136-137.5 °C
• Boiling Point: 386.7±27.0 °C(Predicted)
• PKA: 4.08±0.10(Predicted)
• PSA: 0.00000
• Density: 1.25±0.1 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

6-(1H-Imidazol-1-yl)pyridine-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(1H-iMidazol-1-yl)nicotinaldehyde

There total 4 articles about 6-(1H-iMidazol-1-yl)nicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1H-imidazole (288-32-4) + 2-fluoro-5-formylpyridine (677728-92-6) → 2-(1H-imidazol-1-yl)-5-pyridinecarboxaldehyde (111205-03-9)

Guidance literature:

With triethylamine; cesium fluoride; In tetrahydrofuran; at 20 ℃; for 48h;

DOI:10.1021/acs.jmedchem.1c00401

Reference yield: 49.0%

1H-imidazole (288-32-4) + 6-bromonicotinaldehyde (149806-06-4) → 2-(1H-imidazol-1-yl)-5-pyridinecarboxaldehyde (111205-03-9)

Guidance literature:

With copper(l) iodide; sodium t-butanolate; In dimethyl sulfoxide;

DOI:10.1016/j.poly.2019.114240

Reference yield:

1H-imidazole (288-32-4) + 6-chloronicotinylaldehyde (23100-12-1) → 2-(1H-imidazol-1-yl)-5-pyridinecarboxaldehyde (111205-03-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h;

upstream raw materials:

1H-imidazole

6-bromonicotinaldehyde

6-chloronicotinylaldehyde

2-fluoro-5-formylpyridine

Refernces

• 1、 Wolter, Madita,Valenti, Dario,Cossar, Peter J.,Hristeva, Stanimira,Levy, Laura M.,Genski, Thorsten,Hoffmann, Torsten,Brunsveld, Luc,Tzalis, Dimitrios,Ottmann, Christian. "An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB—Utilizing a Reversible Covalent Tethering Approach". supporting information. p. 8423 - 8436. Retrieved 2021/06/28.
• 2、 -. "Pyridone-pyridyl-imidazolyl and triazolyl compounds and their use as cardiotonic agents". . . Retrieved 2008/06/13.