Sobuzoxane

Base Information

Chemical Name:Sobuzoxane
CAS No.:98631-95-9
Molecular Formula:C₂₂H₃₄N₄O₁₀
Molecular Weight:514.533
Hs Code.:
UNII:R1308VH37P
DSSTox Substance ID:DTXSID5045203
Nikkaji Number:J269.578B
Wikidata:Q27287640
NCI Thesaurus Code:C66540
ChEMBL ID:CHEMBL1256871
Mol file:98631-95-9.mol

Synonyms:1,2-bis(4-isobutoxycarbonyloxymethyl-3,5-dioxopiperazin-1-yl)ethane;MST 16;MST-16;sobuzoxane

Suppliers and Price of Sobuzoxane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Sobuzoxane
5mg
$ 155.00

Crysdot
Sobuzoxane 97%
100mg
$ 840.00

American Custom Chemicals Corporation
SOBUZOXANE 95.00%
25MG
$ 1107.84

American Custom Chemicals Corporation
SOBUZOXANE 95.00%
5MG
$ 719.10

Total 6 raw suppliers

Chemical Property of Sobuzoxane

Chemical Property:

Vapor Pressure:1.51E-17mmHg at 25°C
Melting Point:128-130°; mp 132-133° (Cai, 1989)
Refractive Index:1.513
Boiling Point:664.9 °C at 760 mmHg
PKA:2.75±0.20(Predicted)
Flash Point:355.9 °C
PSA：152.30000
Density:1.272 g/cm³
LogP:-0.38700
Solubility.:DMSO: 19 mg/mL
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:15
Exact Mass:514.22749329
Heavy Atom Count:36
Complexity:743

Purity/Quality:

99.3% ^*data from raw suppliers

Sobuzoxane ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(C)COC(=O)OCN1C(=O)CN(CC1=O)CCN2CC(=O)N(C(=O)C2)COC(=O)OCC(C)C
Description Sobuzoxane, a novel bis(2,6-dioxopiperazine) derivative, was introduced in Japan for the treatment of malignant lymphoma and adult T-cell IeukemiaQmphoma (ATLL), which is resistant to chemotherapy and has a poor prognosis. Sobuzoxane exhibits 8 broad spectrum of antitumor activity. It is a noncleavable complexstabilizing topoisomerase II inhibitor and exerts its function via interfering with the catalytic activity of the enzyme to result in an irreversible inhibition of cell division by blockade of chromosome condensation and segregation. Due to Its unique mode of cytocidai activity, it has no cross resistance with many currently available anticancer agents. Sobuzoxane is reported to significantly inhibit growth of human colon, lung, gastric, and breast cancers and is in clinical trials for these indications.
Uses Sobuzoxane is an inhibitor of DNA topoisomerase II which induces apoptosis.

Technology Process of Sobuzoxane

There total 3 articles about Sobuzoxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 98631-86-8
4,4'-(1,2-ethanediyl)bis(1-hydroxymethyl-2,6-piperazinedione)

: 543-27-1
isobutyl chloroformate

: 98631-95-9
sobuzoxane

Guidance literature:: With pyridine; Ambient temperature;
DOI:10.1248/cpb.37.2976

Reference yield: 88.0%

: 98631-95-9
sobuzoxane

Guidance literature:

Reference yield:

: 1506-47-4
1,2-bis(3,5-dioxopiperazin-1-yl)-ethane

: 98631-95-9
sobuzoxane

Guidance literature:: Multi-step reaction with 2 steps

1: 64.7 percent / dimethylformamide; H₂O / 1.5 h / 130 °C

2: 88 percent / pyridine / Ambient temperature

With pyridine; In water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.37.2976