1,2-Bis(3,5-dioxopiperazin-1-yl)ethane

Base Information

Chemical Name:1,2-Bis(3,5-dioxopiperazin-1-yl)ethane
CAS No.:1506-47-4
Molecular Formula:C₁₀H₁₄N₄O₄
Molecular Weight:254.246
Hs Code.:2933599090
European Community (EC) Number:622-255-2
NSC Number:129942
UNII:QML51S42CD
DSSTox Substance ID:DTXSID40164579
Nikkaji Number:J395.066B
Wikidata:Q27287340
ChEMBL ID:CHEMBL2361164
Mol file:1506-47-4.mol

Synonyms:1,2-bis(3,5-dioxopiperazin-1-yl)ethane;ICRF 154;ICRF-154

Suppliers and Price of 1,2-Bis(3,5-dioxopiperazin-1-yl)ethane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1,2-Bis(3,5-dioxo-1-piperazinyl)ethane
1g
$ 605.00

TRC
1,2-Bis(3,5-dioxo-1-piperazinyl)ethane
500mg
$ 330.00

American Custom Chemicals Corporation
ICRF-154 95.00%
250MG
$ 727.65

Total 13 raw suppliers

Chemical Property of 1,2-Bis(3,5-dioxopiperazin-1-yl)ethane

Chemical Property:

Vapor Pressure:1.01E-11mmHg at 25°C
Melting Point:295-300 °C
Refractive Index:1.54
Boiling Point:539.9 °C at 760 mmHg
PKA:10.71±0.20(Predicted)
Flash Point:280.3 °C
PSA：98.82000
Density:1.361 g/cm³
LogP:-2.56340
Storage Temp.:Room Temperature
Solubility.:Dichloromethane/Methanol (8:2); DMSO; Methanol (heated)
XLogP3:-1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:254.10150494
Heavy Atom Count:18
Complexity:339

Purity/Quality:

97% ^*data from raw suppliers

1,2-Bis(3,5-dioxo-1-piperazinyl)ethane ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(=O)NC(=O)CN1CCN2CC(=O)NC(=O)C2
Uses 1,2-Bis(3,5-dioxo-1-piperazinyl)ethane is an intermediate in synthesizing Bimolane (B386845). It is a catalytic inhibitors of topoisomerase II and has been used for the treatment of cancer, psoriasis and uveitis in humans.

Technology Process of 1,2-Bis(3,5-dioxopiperazin-1-yl)ethane

There total 1 articles about 1,2-Bis(3,5-dioxopiperazin-1-yl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1506-47-4
1,2-bis(3,5-dioxopiperazin-1-yl)-ethane

Guidance literature:

Reference yield:

: 1506-47-4
1,2-bis(3,5-dioxopiperazin-1-yl)-ethane

: 98632-28-1
1,2-bis(4-phenoxycarbonyloxymethyl-3,5-dioxopiperazin-1-yl)ethane

Guidance literature:: Multi-step reaction with 2 steps

1: 64.7 percent / dimethylformamide; H₂O / 1.5 h / 130 °C

2: 60 percent / pyridine / Ambient temperature

With pyridine; In water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.37.2976

Reference yield:

: 1506-47-4
1,2-bis(3,5-dioxopiperazin-1-yl)-ethane

: 98631-91-5
1,2-bis[4-(2-p-chlorophenoxy-2-methylpropionyloxymethyl)-3,5-dioxopiperazin-1-yl]ethane

Guidance literature:: Multi-step reaction with 2 steps

1: 64.7 percent / dimethylformamide; H₂O / 1.5 h / 130 °C

2: 82 percent / pyridine / Ambient temperature

With pyridine; In water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.37.2976