methyl 4-methoxy-1-methyl-1H-indole-2-carboxylate

Base Information

• Chemical Name: methyl 4-methoxy-1-methyl-1H-indole-2-carboxylate
• CAS No.: 111258-25-4
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.24
• Hs Code.: 2933990090
• Mol file: 111258-25-4.mol

Synonyms:4-methoxyindole-2-carboxylate;4-methoxy-1H-indole-2-carboxylic acid methyl ester;Methyl4-Methoxy-2-Indolecarboxylate;methyl 4-methoxy-indole-2-carboxylate;methyl 4-methoxy-1-methyl-1H-indol-2-carboxylate;

Chemical Property of methyl 4-methoxy-1-methyl-1H-indole-2-carboxylate

Chemical Property:

• PSA: 40.46000
• LogP: 1.97350

Purity/Quality:

98%min ^*data from raw suppliers

Methyl4-Methoxy-1-methyl-1H-indole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 4-methoxy-1-methyl-1H-indole-2-carboxylate

There total 7 articles about methyl 4-methoxy-1-methyl-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 4-methoxy-1H-indole-2-carboxylate (111258-23-2) → methyl 4-methoxy-1-methyl-1H-indole-2-carboxylate (111258-25-4)

Guidance literature:

With NaH; ammonium chloride; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

pyruvic acid (4837-89-2) → methyl 4-methoxy-1-methyl-1H-indole-2-carboxylate (111258-25-4)

Guidance literature:

Multi-step reaction with 3 steps

1: FeSO₄/NH₃

3: NaH / dimethylsulfoxide

With ammonia; sodium hydride; iron(II) sulfate; In dimethyl sulfoxide;

DOI:10.1021/jm00400a009

Reference yield:

methyl 4-methoxy-1H-indole-2-carboxylate (111258-23-2) + methyl iodide (74-88-4) → methyl 4-methoxy-1-methyl-1H-indole-2-carboxylate (111258-25-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 18h;

upstream raw materials:

methyl 4-methoxy-1H-indole-2-carboxylate

methyl iodide

4-methoxy-1H-indole-2-carboxylic acid

6-methoxy-2-nitrotoluene

Refernces

• 1、 Fagan, Gay P.,Chapleo, Christopher B.,Lane, Anthony C.,Myers, Malcolm,Roach, Alan G.,et al. "Indoline Analogues of Idazoxan: Potent α2-Antagonists and α1-Agonists". . p. 944 - 948. Retrieved 2007/10/02.