4-Bromo-1,1-bis(4-methoxyphenyl)-butene

Base Information

• Chemical Name: 4-Bromo-1,1-bis(4-methoxyphenyl)-butene
• CAS No.: 111448-46-5
• Molecular Formula: C18H19BrO2
• Molecular Weight: 347.252
• DSSTox Substance ID: DTXSID70551832
• Nikkaji Number: J3.236.878F
• Mol file: 111448-46-5.mol

Synonyms:111448-46-5;4-bromo-1,1-bis(4-methoxyphenyl)-butene;SCHEMBL10361923;DTXSID70551832;FKMUTTNMSCELRY-UHFFFAOYSA-N;1,1'-(4-Bromobut-1-ene-1,1-diyl)bis(4-methoxybenzene)

Chemical Property of 4-Bromo-1,1-bis(4-methoxyphenyl)-butene

Chemical Property:

• XLogP3: 5.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 346.05684
• Heavy Atom Count: 21
• Complexity: 287

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=CCCBr)C2=CC=C(C=C2)OC

Technology Process of 4-Bromo-1,1-bis(4-methoxyphenyl)-butene

There total 5 articles about 4-Bromo-1,1-bis(4-methoxyphenyl)-butene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

bis(p-methoxyphenyl)methylenecyclopropane (28228-81-1) → 1-[4-bromo-1-(4-methoxyphenyl)but-1-en-1-yl]-4-methoxybenzene (111448-46-5)

Guidance literature:

With acetic acid; lithium bromide; at 80 ℃;

DOI:10.1016/j.tet.2003.12.061

Reference yield:

4,4-bis(4-methoxyphenyl)but-3-en-1-ol → 1-[4-bromo-1-(4-methoxyphenyl)but-1-en-1-yl]-4-methoxybenzene (111448-46-5)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2010.11.029

Reference yield:

cyclopropyl[bis(4-methoxyphenyl)]methanol (111448-45-4) → 1-[4-bromo-1-(4-methoxyphenyl)but-1-en-1-yl]-4-methoxybenzene (111448-46-5)

Guidance literature:

With cyclopropylmagnesium bromide; phosphonic acid diethyl ester; In tetrahydrofuran; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/jo400580n

upstream raw materials:

bis(p-methoxyphenyl)methylenecyclopropane

bis(p-methoxyphenyl)methanone

cyclopropyl[bis(4-methoxyphenyl)]methanol