L-Proline, 1-[1-oxo-2-[[(4-phenylbutyl)phosphinyl]oxy]-6-[[(phenylmethoxy)carbonyl] amino]hexyl]-, phenylmethyl ester, (S)-

Base Information

Chemical Name:L-Proline, 1-[1-oxo-2-[[(4-phenylbutyl)phosphinyl]oxy]-6-[[(phenylmethoxy)carbonyl] amino]hexyl]-, phenylmethyl ester, (S)-
CAS No.:111497-22-4
Molecular Formula:C36H45N2O7P
Molecular Weight:648.736
Hs Code.:
Mol file:111497-22-4.mol

Synonyms:

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Chemical Property of L-Proline, 1-[1-oxo-2-[[(4-phenylbutyl)phosphinyl]oxy]-6-[[(phenylmethoxy)carbonyl] amino]hexyl]-, phenylmethyl ester, (S)-

Chemical Property:

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Technology Process of L-Proline, 1-[1-oxo-2-[[(4-phenylbutyl)phosphinyl]oxy]-6-[[(phenylmethoxy)carbonyl] amino]hexyl]-, phenylmethyl ester, (S)-

There total 6 articles about L-Proline, 1-[1-oxo-2-[[(4-phenylbutyl)phosphinyl]oxy]-6-[[(phenylmethoxy)carbonyl] amino]hexyl]-, phenylmethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 768-56-9
4-Phenylbut-1-ene

: 111497-22-4
(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hypophosphite hydrate, H₂SO₄, AIBN / ethanol / 22 h / Heating

2: DCC, DMAP / tetrahydrofuran / 2 h / Ambient temperature

With dmap; sodium hypophosphite; 2,2'-azobis(isobutyronitrile); sulfuric acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00396a033

Reference yield:

: 42491-84-9
(S)-6-Amino-2-hydroxyhexanoic acid

: 111497-22-4
(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / aq. NaOH / 45 h / 0 °C / pH 10

2: 94 percent / Et₃N, hydroxybenzotriazole, DCC / tetrahydrofuran / 1.) 0 deg C_. 3 h, 2.) room temperature, 1 h

3: DCC, DMAP / tetrahydrofuran / 2 h / Ambient temperature

With dmap; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1021/jm00396a033

Reference yield:

: 59221-35-1
(S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid

: 111497-22-4
(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-phenyl-butylphosphinoyloxy)-hexanoyl]-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / Et₃N, hydroxybenzotriazole, DCC / tetrahydrofuran / 1.) 0 deg C_. 3 h, 2.) room temperature, 1 h

2: DCC, DMAP / tetrahydrofuran / 2 h / Ambient temperature

With dmap; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1021/jm00396a033