Technology Process of Ceronapril
There total 15 articles about Ceronapril which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium dihydroxide;
In
methanol;
for 3h;
DOI:10.1021/jm00396a033
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hypophosphite hydrate, H2SO4, AIBN / ethanol / 22 h / Heating
2: DCC, DMAP / tetrahydrofuran / 2 h / Ambient temperature
3: NaIO4 / dioxane; H2O / 16 h
4: 78 percent / H2 / Pd(OH)2/C / methanol / 3 h
With
dmap; sodium periodate; sodium hypophosphite; 2,2'-azobis(isobutyronitrile); sulfuric acid; hydrogen; dicyclohexyl-carbodiimide;
palladium dihydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water;
DOI:10.1021/jm00396a033
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 94 percent / aq. NaOH / 45 h / 0 °C / pH 10
2: 94 percent / Et3N, hydroxybenzotriazole, DCC / tetrahydrofuran / 1.) 0 deg C. 3 h, 2.) room temperature, 1 h
3: DCC, DMAP / tetrahydrofuran / 2 h / Ambient temperature
4: NaIO4 / dioxane; H2O / 16 h
5: 78 percent / H2 / Pd(OH)2/C / methanol / 3 h
With
dmap; sodium hydroxide; sodium periodate; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
palladium dihydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.1021/jm00396a033
