N,N-Dimethyl-1-piperidinecarboxamide

Base Information

• Chemical Name: N,N-Dimethyl-1-piperidinecarboxamide
• CAS No.: 31468-18-5
• Molecular Formula: C8H16 N2 O
• Molecular Weight: 156.228
• NSC Number: 203354
• UNII: E7FN736FYG
• DSSTox Substance ID: DTXSID30185374
• Nikkaji Number: J50.651F
• Wikidata: Q83056395
• Mol file: 31468-18-5.mol

Synonyms:N,N-Dimethyl-1-piperidinecarboxamide;31468-18-5;1-Piperidinecarboxamide, N,N-dimethyl-;N,N-Dimethyl-N',N'-pentamethyleneurea;E7FN736FYG;NSC-203354;N,N-dimethylpiperidine-1-carboxamide;NSC 203354;BRN 1238559;NSC203354;N,N'-pentamethyleneurea;UNII-E7FN736FYG;1-dimethylcarbamoylpiperidine;SCHEMBL378130;WLN: T6NTJ AVN1&1;DTXSID30185374;FYYRPPUFMRGGNG-UHFFFAOYSA-N;1-Piperidinecarboxamide,N-dimethyl-

Chemical Property of N,N-Dimethyl-1-piperidinecarboxamide

Chemical Property:

• Vapor Pressure: 0.0193mmHg at 25°C
• Boiling Point: 252.5°C at 760 mmHg
• PKA: -0.65±0.20(Predicted)
• Flash Point: 101.6°C
• PSA: 23.55000
• Density: 1.024g/cm³
• LogP: 1.09180
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 156.126263138
• Heavy Atom Count: 11
• Complexity: 139

Purity/Quality:

N,N-DIMETHYL-1-PIPERIDINECARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C(=O)N1CCCCC1

Technology Process of N,N-Dimethyl-1-piperidinecarboxamide

There total 3 articles about N,N-Dimethyl-1-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

pyridine (110-86-1) + N,N-Dimethylcarbamoyl chloride (79-44-7) → 1,1-dimethyl-3,3-pentamethylene urea (31468-18-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/ejoc.200500630

Reference yield: 77.5%

piperidine (110-89-4) + N,N-Dimethylcarbamoyl chloride (79-44-7) → 1,1-dimethyl-3,3-pentamethylene urea (31468-18-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1002/jhet.5570430312

Reference yield:

→ 1,1-dimethyl-3,3-pentamethylene urea (31468-18-5)

Guidance literature:

Piperidin, Dimethylcarbamoylchlorid;

DOI:10.1016/0584-8539(70)80167-2

upstream raw materials:

pyridine

N,N-Dimethylcarbamoyl chloride

piperidine

Downstream raw materials:

2-(piperidin-1-yl)-1,3-benzoxazole

2-(piperidin-1-yl)-1H-benzo[d]imidazole