Pentanoic acid, 2-hydroxy-5-[(phenoxyacetyl)amino]-5-phosphono-

Base Information

Chemical Name:Pentanoic acid, 2-hydroxy-5-[(phenoxyacetyl)amino]-5-phosphono-
CAS No.:111603-39-5
Molecular Formula:C₁₃H₁₈NO₈P
Molecular Weight:347.262
Hs Code.:
Mol file:111603-39-5.mol

Synonyms:

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Chemical Property of Pentanoic acid, 2-hydroxy-5-[(phenoxyacetyl)amino]-5-phosphono-

Chemical Property:

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Technology Process of Pentanoic acid, 2-hydroxy-5-[(phenoxyacetyl)amino]-5-phosphono-

There total 16 articles about Pentanoic acid, 2-hydroxy-5-[(phenoxyacetyl)amino]-5-phosphono- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2100-17-6
4-pentenal

: 111603-39-5
2-Hydroxy-5-(2-phenoxy-acetylamino)-5-phosphono-pentanoic acid

Guidance literature:: Multi-step reaction with 13 steps

1: 35 percent / glacial acetic acid / 1.) 22 deg C, 1 h; 2.) 85 deg C, 1.5 h

2: N-methylmorpholine oxide dihydrate, osmium tetroxide / tetrahydrofuran; H₂O / 22 °C

3: 81 percent / 2N NaOH / H₂O / 25 °C

4: dicyclohexylcarbodiimide, pyridine / CH₂Cl₂

5: methanol

6: 89 percent / O₂ / 10percent Pt/C / H₂O / 36 h / 50 °C

7: oxalyl chloride, dimethylformamide / CH₂Cl₂ / 1.) 30 min., 0 deg C; 2.) 45 min., r.t.

8: triethylamine / CH₂Cl₂ / 12 h / 21 °C

9: H₂ / 10percent Pt/C / ethyl acetate / 3 h / 760 Torr

10: triethylamine / CH₂Cl₂ / 12 h / 21 °C

11: 92 percent / trimethylsilyl bromide, isobutylene / CH₂Cl₂ / 2 h / 21 °C

12: trifluoroacetic acid / CH₂Cl₂ / 2.5 h / 21 °C

13: 1N HCl

With pyridine; hydrogenchloride; sodium hydroxide; osmium(VIII) oxide; oxalyl dichloride; trimethylsilyl bromide; hydrogen; oxygen; acetic acid; 4-methylmorpholine N-oxide; triethylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; trifluoroacetic acid; isobutene; platinum on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;

Reference yield:

: (2-Hydroxy-6-hydroxymethyl-2-oxo-2λ⁵-[1,2]oxaphosphinan-3-yl)-carbamic acid benzyl ester

: 111603-39-5
2-Hydroxy-5-(2-phenoxy-acetylamino)-5-phosphono-pentanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: methanol

2: 89 percent / O₂ / 10percent Pt/C / H₂O / 36 h / 50 °C

3: oxalyl chloride, dimethylformamide / CH₂Cl₂ / 1.) 30 min., 0 deg C; 2.) 45 min., r.t.

4: triethylamine / CH₂Cl₂ / 12 h / 21 °C

5: H₂ / 10percent Pt/C / ethyl acetate / 3 h / 760 Torr

6: triethylamine / CH₂Cl₂ / 12 h / 21 °C

7: 92 percent / trimethylsilyl bromide, isobutylene / CH₂Cl₂ / 2 h / 21 °C

8: trifluoroacetic acid / CH₂Cl₂ / 2.5 h / 21 °C

9: 1N HCl

With hydrogenchloride; oxalyl dichloride; trimethylsilyl bromide; hydrogen; oxygen; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; isobutene; platinum on activated charcoal; In methanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 111603-32-8
(1-Benzyloxycarbonylamino-4,5-dihydroxy-pentyl)-phosphonic acid

: 111603-39-5
2-Hydroxy-5-(2-phenoxy-acetylamino)-5-phosphono-pentanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1: dicyclohexylcarbodiimide, pyridine / CH₂Cl₂

2: methanol

3: 89 percent / O₂ / 10percent Pt/C / H₂O / 36 h / 50 °C

4: oxalyl chloride, dimethylformamide / CH₂Cl₂ / 1.) 30 min., 0 deg C; 2.) 45 min., r.t.

5: triethylamine / CH₂Cl₂ / 12 h / 21 °C

6: H₂ / 10percent Pt/C / ethyl acetate / 3 h / 760 Torr

7: triethylamine / CH₂Cl₂ / 12 h / 21 °C

8: 92 percent / trimethylsilyl bromide, isobutylene / CH₂Cl₂ / 2 h / 21 °C

9: trifluoroacetic acid / CH₂Cl₂ / 2.5 h / 21 °C

10: 1N HCl

With pyridine; hydrogenchloride; oxalyl dichloride; trimethylsilyl bromide; hydrogen; oxygen; triethylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; trifluoroacetic acid; isobutene; platinum on activated charcoal; In methanol; dichloromethane; water; ethyl acetate;