6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-, 1-oxide

Base Information

Chemical Name:6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-, 1-oxide
CAS No.:84446-20-8
Molecular Formula:C19H21N5O3
Molecular Weight:367.407
Hs Code.:
DSSTox Substance ID:DTXSID50233422
Wikidata:Q83114937

Synonyms:BRN 4584184;6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-, 1-oxide;84446-20-8;DTXSID50233422;LS-133130

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-, 1-oxide

Chemical Property:

Vapor Pressure:2.05E-15mmHg at 25°C
Boiling Point:622.5°C at 760 mmHg
Flash Point:330.2°C
Density:1.39g/cm³
XLogP3:-0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:367.16443955
Heavy Atom Count:27
Complexity:566

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2[N+](=CC=C4)[O-]

Technology Process of 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-, 1-oxide

There total 9 articles about 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-, 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 109-01-3
1-methyl-piperazine

: 84446-19-5
1-oxo-11-(2'-chloroacetyl)-5,11-dihydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one

: 84446-20-8
1-oxo-11,2'-(4''-methylpiperazin-1''-yl)acetyl-5,11-dihydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one

Guidance literature:: In toluene; at 80 ℃; for 2h;

Reference yield:

: 84446-21-9
3-(2'-chlorobenzoyl)amino-2-chloropyridine

: 84446-20-8
1-oxo-11,2'-(4''-methylpiperazin-1''-yl)acetyl-5,11-dihydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / 40percent H₂O₂, acetic acid / 24 h / 55 - 60 °C / bath temperature

2: 8.96 g / conc. NH₄OH, CuSO₄*5H₂O, NaCl / 5 h / 80 °C

3: 96 percent / 5percent aq. HCl / various solvent(s) / 1.5 h / 110 °C / bath temperature

4: acetonitrile / 2 h / 80 °C

5: 95 percent / toluene / 2 h / 80 °C

With hydrogenchloride; ammonium hydroxide; dihydrogen peroxide; copper(II) sulfate; acetic acid; sodium chloride; In toluene; acetonitrile;

Reference yield:

: 84446-17-3
3-(2'-bromobenzoyl)amino-2-chloropyridine

: 84446-20-8
1-oxo-11,2'-(4''-methylpiperazin-1''-yl)acetyl-5,11-dihydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / 40percent H₂O₂, acetic acid / 24 h / 55 - 60 °C / bath temperature

2: conc. NH₄OH, CuSO₄*5H₂O, NaCl / 3 h / 60 °C

3: 96 percent / 5percent aq. HCl / various solvent(s) / 1.5 h / 110 °C / bath temperature

4: acetonitrile / 2 h / 80 °C

5: 95 percent / toluene / 2 h / 80 °C

With hydrogenchloride; ammonium hydroxide; dihydrogen peroxide; copper(II) sulfate; acetic acid; sodium chloride; In toluene; acetonitrile;