(R)-5-Methyloxazolidin-2-one

Base Information

• Chemical Name: (R)-5-Methyloxazolidin-2-one
• CAS No.: 111688-35-8
• Molecular Formula: C4H7NO2
• Molecular Weight: 101.10400
• Mol file: 111688-35-8.mol

Synonyms:5-(R)-methyl-oxazolidin-2-one;(R)-5-Methyl-oxazolidin-2-one;(R)-5-methyloxazolidin-2-one;(5R)-5-methyl-oxazolidin-2-one;

Chemical Property of (R)-5-Methyloxazolidin-2-one

Chemical Property:

• Boiling Point: 302.6±9.0 °C(Predicted)
• PKA: 12.82±0.40(Predicted)
• PSA: 38.33000
• Density: 1.095±0.06 g/cm3(Predicted)
• LogP: 0.44350

Purity/Quality:

97% ^*data from raw suppliers

(R)-5-Methyloxazolidin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-5-Methyloxazolidin-2-one

There total 4 articles about (R)-5-Methyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

(R)-3-hydroxy-butyric acid hydrazide → (R)-5-methyl-oxazolidin-2-one (111688-35-8)

Guidance literature:

With sulfuric acid; sodium nitrite; In water; at 20 ℃; for 2h; Inert atmosphere;

Reference yield: 50.0%

(2R)-hydroxypropylamine (2799-16-8) + carbon dioxide (124-38-9,18923-20-1) → (R)-5-methyl-oxazolidin-2-one (111688-35-8)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 25 - 150 ℃; for 24h; under 5320.36 Torr; Schlenk technique; Autoclave;

DOI:10.1016/j.tetlet.2013.06.100

Reference yield:

(2R)-hydroxypropylamine (2799-16-8) + Diethyl carbonate (105-58-8,76619-83-5) → (R)-5-methyl-oxazolidin-2-one (111688-35-8)

Guidance literature:

With potassium carbonate; at 150 ℃; for 3h;

upstream raw materials:

phosgene

(2R)-hydroxypropylamine

Diethyl carbonate

carbon dioxide

Downstream raw materials:

(2R,5S)-4-{2-[6-(4-fluoro-benzyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl]-2-oxo-ethyl}-2-methyl-5-((R)-5-methyl-2-oxo-oxazolidin-3-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester