Ethanone, 2,2,2-trifluoro-1-[5-(4-methoxy-3-nitrobenzoyl)-3-thienyl]-, 1-[O-[(4-methylphenyl)sulfonyl]oxime], (Z)-

Base Information

Chemical Name:Ethanone, 2,2,2-trifluoro-1-[5-(4-methoxy-3-nitrobenzoyl)-3-thienyl]-, 1-[O-[(4-methylphenyl)sulfonyl]oxime], (Z)-
CAS No.:111690-71-2
Molecular Formula:C₂₁H₁₅F₃N₂O₇S₂
Molecular Weight:528.487
Hs Code.:
Mol file:111690-71-2.mol

Synonyms:

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Chemical Property of Ethanone, 2,2,2-trifluoro-1-[5-(4-methoxy-3-nitrobenzoyl)-3-thienyl]-, 1-[O-[(4-methylphenyl)sulfonyl]oxime], (Z)-

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Technology Process of Ethanone, 2,2,2-trifluoro-1-[5-(4-methoxy-3-nitrobenzoyl)-3-thienyl]-, 1-[O-[(4-methylphenyl)sulfonyl]oxime], (Z)-

There total 7 articles about Ethanone, 2,2,2-trifluoro-1-[5-(4-methoxy-3-nitrobenzoyl)-3-thienyl]-, 1-[O-[(4-methylphenyl)sulfonyl]oxime], (Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 111690-64-3,111690-65-4
1-<2-(3-nitro-4-methoxybenzoyl)-4-thienyl>-2,2,2-trifluoroethanone oxime

: 98-59-9
p-toluenesulfonyl chloride

: 111690-70-1,111690-71-2
1-<2-(3-nitro-4-methoxybenzoyl)-4-thienyl>-2,2,2-trifluoroethanone O-<(4-methylphenyl)sulfonyl>oxime

Guidance literature:: With pyridine; at 80 ℃; for 4h;
DOI:10.1021/jo00237a035

Reference yield:

: 58777-65-4
4-Bromothiophene-2-carboxylic acid chloride

: 111690-70-1,111690-71-2
1-<2-(3-nitro-4-methoxybenzoyl)-4-thienyl>-2,2,2-trifluoroethanone O-<(4-methylphenyl)sulfonyl>oxime

Guidance literature:: Multi-step reaction with 7 steps

1: AlCl₃ / CH₂Cl₂ / 1.) 0 deg C, 0.5 h, 2.) RT, 0.5 h

2: p-toluenesulfonic acid / benzene / 89.5 h / Heating

3: 1.) n-BuLi / 1.) ether, hexane, -78 deg C, 55 min, 2.) 20 min

4: 90 percent / 1 N HCl / tetrahydrofuran / 1 h / Heating

5: 78 percent / concd H₂SO₄, concd HNO₃ / CH₂Cl₂ / 1.5 h / 0 °C

6: 42 percent / hydroxylamine hydrochloride, pyridine / ethanol / 3.5 h / Heating

7: 85 percent / pyridine / 4 h / 80 °C

With pyridine; hydrogenchloride; n-butyllithium; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; nitric acid; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; benzene;
DOI:10.1021/jo00237a035

Reference yield:

: 66938-33-8
(4-bromo-2-thienyl)(4-methoxyphenyl)methanone

: 111690-70-1,111690-71-2
1-<2-(3-nitro-4-methoxybenzoyl)-4-thienyl>-2,2,2-trifluoroethanone O-<(4-methylphenyl)sulfonyl>oxime

Guidance literature:: Multi-step reaction with 6 steps

1: p-toluenesulfonic acid / benzene / 89.5 h / Heating

2: 1.) n-BuLi / 1.) ether, hexane, -78 deg C, 55 min, 2.) 20 min

3: 90 percent / 1 N HCl / tetrahydrofuran / 1 h / Heating

4: 78 percent / concd H₂SO₄, concd HNO₃ / CH₂Cl₂ / 1.5 h / 0 °C

5: 42 percent / hydroxylamine hydrochloride, pyridine / ethanol / 3.5 h / Heating

6: 85 percent / pyridine / 4 h / 80 °C

With pyridine; hydrogenchloride; n-butyllithium; sulfuric acid; hydroxylamine hydrochloride; nitric acid; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; benzene;
DOI:10.1021/jo00237a035