(4-Bromo-2-thienyl)(4-methoxyphenyl)methanone

Base Information

• Chemical Name: (4-Bromo-2-thienyl)(4-methoxyphenyl)methanone
• CAS No.: 66938-33-8
• Molecular Formula: C₁₂H₉BrO₂S
• Molecular Weight: 297.172
• DSSTox Substance ID: DTXSID20553962
• Wikidata: Q82434716

Synonyms:66938-33-8;(4-bromo-2-thienyl)(4-methoxyphenyl)methanone;DTXSID20553962;AKOS013629388;(4-Bromothiophen-2-yl)(4-methoxyphenyl)methanone

Chemical Property of (4-Bromo-2-thienyl)(4-methoxyphenyl)methanone

Chemical Property:

• PSA: 54.54000
• LogP: 3.75020
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 295.95066
• Heavy Atom Count: 16
• Complexity: 251

Purity/Quality:

99% ^*data from raw suppliers

(4-BROMO-2-THIENYL)-(4-METHOXYPHENYL)METHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C2=CC(=CS2)Br

Technology Process of (4-Bromo-2-thienyl)(4-methoxyphenyl)methanone

There total 3 articles about (4-Bromo-2-thienyl)(4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-thiophene-2-carboxylic acid (16694-18-1) → (4-bromo-2-thienyl)(4-methoxyphenyl)methanone (66938-33-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / CHCl₃ / 2 h / Heating

2: AlCl₃ / CH₂Cl₂ / 1.) 0 deg C, 0.5 h, 2.) RT, 0.5 h

With aluminium trichloride; thionyl chloride; In dichloromethane; chloroform;

DOI:10.1021/jo00237a035

Reference yield:

4-Bromothiophene-2-carboxylic acid chloride (58777-65-4) + methoxybenzene (100-66-3) → (4-bromo-2-thienyl)(4-methoxyphenyl)methanone (66938-33-8)

Guidance literature:

With aluminium trichloride; In dichloromethane; Yield given; 1.) 0 deg C, 0.5 h, 2.) RT, 0.5 h;

DOI:10.1021/jo00237a035

Reference yield:

→ (4-bromo-2-thienyl)(4-methoxyphenyl)methanone (66938-33-8)

Guidance literature:

Anisol, 4-Bromthiophen-2-carbonsaeurechlorid, AlCl3;

upstream raw materials:

4-Bromothiophene-2-carboxylic acid chloride

methoxybenzene

4-bromo-thiophene-2-carboxylic acid

Downstream raw materials:

(4-trifluoroacetyl-2-thienyl)(4-methoxyphenyl)methanone hydrate

(3,4-Diamino-phenyl)-[4-(3-trifluoromethyl-3H-diazirin-3-yl)-thiophen-2-yl]-methanone

(4-trifluoroacetyl-2-thienyl)(3-nitro-4-methoxyphenyl)methanone

<4-(1-azi-2,2,2-trifluoroethyl)-2-thienyl>(3-nitro-4-aminophenyl)methanone

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