3-(2-butylphenyl)-5-(3-methoxyphenyl)-2H-1,2,4-triazole

Base Information

• Chemical Name: 3-(2-butylphenyl)-5-(3-methoxyphenyl)-2H-1,2,4-triazole
• CAS No.: 85303-89-5
• Molecular Formula: C₁₉H₂₁N₃O
• Molecular Weight: 307.395
• Mol file: 85303-89-5.mol

Synonyms:1H-1,2,4-Triazole, 3-(2-butylphenyl)-5-(3-methoxyphenyl)-;s-Triazole, 3-(o-butylphenyl)-5-(m-methoxyphenyl)-;3-(2-butylphenyl)-5-(3-methoxyphenyl)-2H-1,2,4-triazole;

Chemical Property of 3-(2-butylphenyl)-5-(3-methoxyphenyl)-2H-1,2,4-triazole

Chemical Property:

• Vapor Pressure: 7.85E-11mmHg at 25°C
• Refractive Index: 1.581
• Boiling Point: 517.9 °C at 760 mmHg
• Flash Point: 183.1 °C
• PSA: 50.80000
• Density: 1.119 g/cm³
• LogP: 4.48990

Purity/Quality:

99% ^*data from raw suppliers

3-(O-BUTYLPHENYL)-5-(M-METHOXYPHENYL)-S-TRIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-butylphenyl)-5-(3-methoxyphenyl)-2H-1,2,4-triazole

There total 5 articles about 3-(2-butylphenyl)-5-(3-methoxyphenyl)-2H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-butylbenzoic acid (54887-23-9) → 3-(2-Butyl-phenyl)-5-(3-methoxy-phenyl)-1H-[1,2,4]triazole (85303-89-5)

Guidance literature:

Multi-step reaction with 5 steps

1: SOCl₂ / 2 h / Heating

2: Et₃N / CH₂Cl₂ / 2 h

3: 37percent aq. HCl / 0.5 h

4: 1.) MeCN, reflux, 1 h, 2.) 110 deg C, 2 h

5: 0.17 h / 200 °C

With hydrogenchloride; thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1021/jm00362a018

Reference yield:

2-butylbenzoyl chloride (54887-24-0) → 3-(2-Butyl-phenyl)-5-(3-methoxy-phenyl)-1H-[1,2,4]triazole (85303-89-5)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 2 h

2: 37percent aq. HCl / 0.5 h

3: 1.) MeCN, reflux, 1 h, 2.) 110 deg C, 2 h

4: 0.17 h / 200 °C

With hydrogenchloride; triethylamine; In dichloromethane;

DOI:10.1021/jm00362a018

Reference yield:

2-Butyl-benzoic acid [1-amino-1-(3-methoxy-phenyl)-meth-(Z)-ylidene]-hydrazide → 3-(2-Butyl-phenyl)-5-(3-methoxy-phenyl)-1H-[1,2,4]triazole (85303-89-5)

Guidance literature:

at 200 ℃; for 0.166667h; Yield given;

DOI:10.1021/jm00362a018

upstream raw materials:

2-butylbenzoic acid

2-butylbenzoyl chloride

o-(n-butyl)benzhydrazide