Carbamic acid, [1-[[[2-[(1H-benzimidazol-2-ylthio)methyl]phenyl]amino]carbonyl]-3-meth ylbutyl]-, phenylmethyl ester, (S)-

Base Information

Chemical Name:Carbamic acid, [1-[[[2-[(1H-benzimidazol-2-ylthio)methyl]phenyl]amino]carbonyl]-3-meth ylbutyl]-, phenylmethyl ester, (S)-
CAS No.:111881-37-9
Molecular Formula:C28H30N4O3S
Molecular Weight:502.637
Hs Code.:
Mol file:111881-37-9.mol

Synonyms:

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Chemical Property of Carbamic acid, [1-[[[2-[(1H-benzimidazol-2-ylthio)methyl]phenyl]amino]carbonyl]-3-meth ylbutyl]-, phenylmethyl ester, (S)-

Chemical Property:

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Technology Process of Carbamic acid, [1-[[[2-[(1H-benzimidazol-2-ylthio)methyl]phenyl]amino]carbonyl]-3-meth ylbutyl]-, phenylmethyl ester, (S)-

There total 4 articles about Carbamic acid, [1-[[[2-[(1H-benzimidazol-2-ylthio)methyl]phenyl]amino]carbonyl]-3-meth ylbutyl]-, phenylmethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2018-66-8
Z-Leu-OH

: 111881-37-9
{(S)-1-[2-(1H-Benzoimidazol-2-ylsulfanylmethyl)-phenylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / hexamethylphosphoric acid triamide; acetonitrile / 0.25 h / -5 - 0 °C

2: hexamethylphosphoric acid triamide; acetonitrile / 4 h / Ambient temperature

3: SOCl₂ / benzene / 0.33 h / Heating

4: NaOH / H₂O; ethanol / 2 h / Ambient temperature

With sodium hydroxide; thionyl chloride; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; water; acetonitrile; benzene;
DOI:10.1016/0223-5234(91)90024-H

Reference yield:

: 87052-59-3
N-Z-Leucine chloride

: 111881-37-9
{(S)-1-[2-(1H-Benzoimidazol-2-ylsulfanylmethyl)-phenylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hexamethylphosphoric acid triamide; acetonitrile / 4 h / Ambient temperature

2: SOCl₂ / benzene / 0.33 h / Heating

3: NaOH / H₂O; ethanol / 2 h / Ambient temperature

With sodium hydroxide; thionyl chloride; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; water; acetonitrile; benzene;
DOI:10.1016/0223-5234(91)90024-H

Reference yield:

: 111881-68-6
[(S)-1-(2-Hydroxymethyl-phenylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester

: 111881-37-9
{(S)-1-[2-(1H-Benzoimidazol-2-ylsulfanylmethyl)-phenylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / benzene / 0.33 h / Heating

2: NaOH / H₂O; ethanol / 2 h / Ambient temperature

With sodium hydroxide; thionyl chloride; In ethanol; water; benzene;
DOI:10.1016/0223-5234(91)90024-H