Technology Process of 2,2'-Bipyridine, 4,4'-bis[4-(bromomethyl)phenyl]-
There total 6 articles about 2,2'-Bipyridine, 4,4'-bis[4-(bromomethyl)phenyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) CuI; 2.) ClCO(tBu); 3.) S8 / 3.) 200 deg C
2: 77 percent / N,N-dimethylaniline, NaNH2 / 6.5 h / 158 - 160 °C
3: 1.) HBr,Br2; 2.) NaNO2; 3.) NaOH / 1.) water, -16 deg C, 20 min; 2.) 0 deg C, 30 min; 3.) 20 deg C, 1 h
4: 27 percent / PPh3, Zn dust / Ni(PPh3)2Cl2 / dimethylformamide / 17.5 h / 50 °C
5: 54 percent / NBS, peroxide de benzoyle / benzene / 19 h / Heating
With
sulfur; sodium hydroxide; N-Bromosuccinimide; copper(l) iodide; Perbenzoic acid; hydrogen bromide; bromine; pivaloyl chloride; sodium amide; N,N-dimethyl-aniline; triphenylphosphine; zinc; sodium nitrite;
bis(triphenylphosphine)nickel(II) chloride;
In
N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)90027-4
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 77 percent / N,N-dimethylaniline, NaNH2 / 6.5 h / 158 - 160 °C
2: 1.) HBr,Br2; 2.) NaNO2; 3.) NaOH / 1.) water, -16 deg C, 20 min; 2.) 0 deg C, 30 min; 3.) 20 deg C, 1 h
3: 27 percent / PPh3, Zn dust / Ni(PPh3)2Cl2 / dimethylformamide / 17.5 h / 50 °C
4: 54 percent / NBS, peroxide de benzoyle / benzene / 19 h / Heating
With
sodium hydroxide; N-Bromosuccinimide; Perbenzoic acid; hydrogen bromide; bromine; sodium amide; N,N-dimethyl-aniline; triphenylphosphine; zinc; sodium nitrite;
bis(triphenylphosphine)nickel(II) chloride;
In
N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)90027-4