2-FLUOROPHENYL CYCLOPENTYL KETONE

Base Information

• Chemical Name: 2-FLUOROPHENYL CYCLOPENTYL KETONE
• CAS No.: 111982-45-7
• Molecular Formula: C12H13FO
• Molecular Weight: 192.233
• Mol file: 111982-45-7.mol

Synonyms:cyclopentyl-(2-fluoro-phenyl)-methanone;2-FLUOROPHENYL CYCLOPENTYL KETONE;Methanone,cyclopentyl(2-fluorophenyl);

Chemical Property of 2-FLUOROPHENYL CYCLOPENTYL KETONE

Chemical Property:

• Vapor Pressure: 0.00498mmHg at 25°C
• Boiling Point: 275.8oC at 760 mmHg
• Flash Point: 110.9oC
• PSA: 17.07000
• Density: 1.131g/cm3
• LogP: 3.19860
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2-FluorophenylCyclopentylKetone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUOROPHENYL CYCLOPENTYL KETONE

There total 2 articles about 2-FLUOROPHENYL CYCLOPENTYL KETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Cyclopentyl bromide (137-43-9) + 2-fluorobenzonitrile (394-47-8) → cyclopentyl(2-fluorophenyl)methanone (111982-45-7)

Guidance literature:

Cyclopentyl bromide; With iodine; magnesium; In tetrahydrofuran; at 20 ℃; Reflux;

2-fluorobenzonitrile; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; for 4h; Inert atmosphere; Reflux;

With sulfuric acid; water; In tetrahydrofuran; for 4h; Reagent/catalyst; Solvent; Time;

DOI:10.1080/00397911.2014.885053

Reference yield: 40.0%

2-fluorobenzonitrile (394-47-8) + cyclopentylmagnesium bromide (33240-34-5) → cyclopentyl(2-fluorophenyl)methanone (111982-45-7)

Guidance literature:

2-fluorobenzonitrile; cyclopentylmagnesium bromide; With copper(I) bromide; In tetrahydrofuran; at 60 ℃; for 15h;

With sulfuric acid; water; In tetrahydrofuran; at 0 ℃; for 15h;

Reference yield: 96.0%

cyclopentyl(2-fluorophenyl)methanone (111982-45-7) → α-bromocyclopentyl-(2-fluorophenyl)ketone (1616657-67-0)

Guidance literature:

cyclopentyl(2-fluorophenyl)methanone; With hydrogen bromide; In water; at 20 ℃; for 0.0833333h; Darkness;

With lithium chloride; In water; at 20 ℃; for 0.0166667h; Darkness;

With dihydrogen peroxide; In water; at 70 ℃; for 1.5h; Darkness;

DOI:10.1080/00397911.2014.885053

upstream raw materials:

2-fluorobenzonitrile

cyclopentylmagnesium bromide

Cyclopentyl bromide

Downstream raw materials:

α-bromocyclopentyl-(2-fluorophenyl)ketone

α-hydroxycyclopentyl-(2-flourophenyl)-N-methylamine

(2-fluorophenyl)(1-hydroxycyclopentyl)methanone

(±)-2-(2-fluorophenyl)-2-(methylamino)cyclohexanone

Refernces

• 1、 Moghimi, Abolghasem,Rahmani, Siyavash,Zare, Reza,Sadeghzadeh, Morteza. "Synthesis of 2-(2-fluorophenyl)-2-methylamino-cyclohexanone as a new ketamine derivative". . p. 2021 - 2028. Retrieved 2014/07/07.