1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid

Base Information

• Chemical Name: 1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid
• CAS No.: 78190-11-1
• Molecular Formula: C14H17NO4
• Molecular Weight: 263.293
• Hs Code.: 29333990
• Mol file: 78190-11-1.mol

Synonyms:1,3-Piperidinedicarboxylicacid, 1-benzyl ester (7CI);N-Benzyloxycarbonylnipecotic acid;NSC 34059;

Chemical Property of 1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid

Chemical Property:

• Appearance/Colour: Light brown solid
• Vapor Pressure: 1.16E-08mmHg at 25°C
• Melting Point: 90-94 °C
• Boiling Point: 443.9 °C at 760 mmHg
• PKA: 4.48±0.20(Predicted)
• Flash Point: 222.3 °C
• PSA: 66.84000
• Density: 1.265 g/cm³
• LogP: 2.05770
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol

Purity/Quality:

98% ^*data from raw suppliers

N-Cbz-piperidine-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-37/39-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid

There total 3 articles about 1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzyl chloroformate (501-53-1,94274-21-2) + nipecotic acid (498-95-3,262853-93-0) → 1-benzyloxycarbonylpiperidine-3-carboxylic acid (78190-11-1)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane;

DOI:10.1016/0040-4039(95)02378-X

Reference yield: 97.0%

→ 1-benzyloxycarbonylpiperidine-3-carboxylic acid (78190-11-1)

Guidance literature:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + 3-formylpiperidine-1-carboxylic acid tert-butyl ester (118156-93-7) → 1-benzyloxycarbonylpiperidine-3-carboxylic acid (78190-11-1)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; hexane;

upstream raw materials:

benzyl chloroformate

nipecotic acid

3-formylpiperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

N-benzyloxycarbonyl nipecotic acid methyl ester

1-[(benzyloxy)carbonyl]piperidine-3-carbonyl chloride

3-{5-[(S)-2-tert-Butoxycarbonyl-2-(2,2,2-trifluoro-acetylamino)-ethyl]-2-methoxy-phenylcarbamoyl}-piperidine-1-carboxylic acid benzyl ester

3-Amino-3-methyl-piperidine-1-carboxylic acid benzyl ester