2-[(2-amino-6-oxo-1,4,5,6-tetrahydro-9H-purin-9-yl)methoxy]ethyl glycinate

Base Information

• Chemical Name: 2-[(2-amino-6-oxo-1,4,5,6-tetrahydro-9H-purin-9-yl)methoxy]ethyl glycinate
• CAS No.: 84499-61-6
• Molecular Formula: C₁₀H₁₄N₆O₄*ClH
• Molecular Weight: 318.72
• Mol file: 84499-61-6.mol

Synonyms:

Chemical Property of 2-[(2-amino-6-oxo-1,4,5,6-tetrahydro-9H-purin-9-yl)methoxy]ethyl glycinate

Chemical Property:

• Density: 1.74g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(2-amino-6-oxo-1,4,5,6-tetrahydro-9H-purin-9-yl)methoxy]ethyl glycinate

There total 3 articles about 2-[(2-amino-6-oxo-1,4,5,6-tetrahydro-9H-purin-9-yl)methoxy]ethyl glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

9-<<2-(azidoacetoxy)ethoxy>methyl>guanine (84499-68-3) → 9-<<2-(glycyloxy)ethoxy>methyl>guanine hydrochloride (84499-61-6)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; water; for 1.5h; under 2068.6 Torr;

DOI:10.1021/jm00358a029

Reference yield:

acycloguanosine (59277-89-3) + 2-azidoacetyl chloride (30426-58-5) → 9-<<2-(azidoacetoxy)ethoxy>methyl>guanine (84499-68-3) + 9-<<2-(glycyloxy)ethoxy>methyl>guanine hydrochloride (84499-61-6)

Guidance literature:

With sodium hydrogencarbonate; triethylamine; In N-methyl-acetamide; diethyl ether; ethanol; dichloromethane;

Reference yield:

acycloguanosine (59277-89-3) → 9-<<2-(glycyloxy)ethoxy>methyl>guanine hydrochloride (84499-61-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / triethylamine / dimethylformamide / 1 h / 0 °C

2: 65 percent / H₂, 1N HCl / 10percent Pd/C / H₂O; ethanol / 1.5 h / 2068.6 Torr

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00358a029

upstream raw materials:

9-<<2-(azidoacetoxy)ethoxy>methyl>guanine

acycloguanosine

2-azidoacetyl chloride