3-PHENOXYPHENYLACETIC ACID

Base Information

• Chemical Name: 3-PHENOXYPHENYLACETIC ACID
• CAS No.: 32852-81-6
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• Hs Code.: 29189900
• Mol file: 32852-81-6.mol

Synonyms:Aceticacid, (m-phenoxyphenyl)- (8CI);2-(3-Phenoxyphenyl)acetic acid;2-(3-Phenoxyphenyl)ethanoic acid;RU 5142;

Chemical Property of 3-PHENOXYPHENYLACETIC ACID

Chemical Property:

• Vapor Pressure: 1.25E-06mmHg at 25°C
• Melting Point: 88-91 °C(lit.)
• Refractive Index: 1.596
• Boiling Point: 385.378 °C at 760 mmHg
• PKA: 4.15±0.10(Predicted)
• Flash Point: 147.396 °C
• PSA: 46.53000
• Density: 1.218 g/cm³
• LogP: 3.10600
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Phenoxyphenylacetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-PHENOXYPHENYLACETIC ACID

There total 14 articles about 3-PHENOXYPHENYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2--(6--methoxynaphthalen--2--yl)acetaldehyde (109330-01-0) → (3-phenoxyphenyl)acetic acid (32852-81-6)

Guidance literature:

With sodium chlorite; potassium dihydrogenphosphate; 2,3-Dimethyl-2-butene; In water; tert-butyl alcohol; at 20 ℃; for 0.733333h;

DOI:10.1021/ml3001616

Reference yield: 99.0%

→ (3-phenoxyphenyl)acetic acid (32852-81-6)

Guidance literature:

With sodium chlorite; potassium dihydrogenphosphate; 2,3-Dimethyl-2-butene; In water; tert-butyl alcohol; at 20 ℃; for 0.666667h;

Reference yield: 90.0%

3-phenoxyphenylacetonitrile (51632-29-2) → (3-phenoxyphenyl)acetic acid (32852-81-6)

Guidance literature:

With sulfuric acid; In acetic acid; for 0.75h; Heating;

DOI:10.1002/ardp.19833160705

upstream raw materials:

3-phenoxyphenylacetonitrile

3-phenoxybenzyl chloride

3-phenoxytoluene

potassium cyanide

Downstream raw materials:

methyl 2-(3-phenoxyphenyl)acetate

N-[2-(2,5-Dimethoxy-phenyl)-ethyl]-2-(3-phenoxy-phenyl)-acetamide

m-phenoxyphenylacetic acid chloride

4-methyl-2-[2-(3-phenoxyphenyl)acetylamino]-thiophene-3-carboxylic acid methyl ester

Refernces

• 1、 -. "COMPOSITIONS AND METHODS FOR SUBSTRATE-SELECTIVE INHIBITION OF ENDOCANNABINOID OXYGENATION". Page/Page column 57; 59. . Retrieved 2014/02/15.
• 2、 Windsor, Matthew A.,Hermanson, Daniel J.,Kingsley, Philip J.,Xu, Shu,Crews, Brenda C.,Ho, Winnie,Keenan, Catherine M.,Banerjee, Surajit,Sharkey, Keith A.,Marnett, Lawrence J.. "Substrate-selective inhibition of cyclooxygenase-2: Development and evaluation of achiral profen probes". supporting information. p. 759 - 763. Retrieved 2012/10/29.