2-(3-Phenoxyphenyl)acetaldehyde

Base Information

• Chemical Name: 2-(3-Phenoxyphenyl)acetaldehyde
• CAS No.: 109330-01-0
• Molecular Formula: C14H12 O2
• Molecular Weight: 212.248
• Hs Code.: 2912499000
• European Community (EC) Number: 836-317-3
• Mol file: 109330-01-0.mol

Synonyms:2-(3-Phenoxyphenyl)acetaldehyde;109330-01-0;Benzeneacetaldehyde, 3-phenoxy-;SCHEMBL5311815;MFCD10566816;AKOS014197772;ETHYL4-(2-IODOETHOXY)BUTANOATE;CS-0237658;EN300-1861450;A1-42079;Z1250885339

Chemical Property of 2-(3-Phenoxyphenyl)acetaldehyde

Chemical Property:

• Boiling Point: 338.2±25.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.116±0.06 g/cm3(Predicted)
• LogP: 3.22030
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 212.083729621
• Heavy Atom Count: 16
• Complexity: 209

Purity/Quality:

99% ^*data from raw suppliers

(4-Phenoxyphenyl)acetaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OC2=CC=CC(=C2)CC=O

Technology Process of 2-(3-Phenoxyphenyl)acetaldehyde

There total 7 articles about 2-(3-Phenoxyphenyl)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(methoxymethyl)triphenylphosphonium chloride (4009-98-7) + 3-Phenoxybenzaldehyde (39515-51-0) → 2--(6--methoxynaphthalen--2--yl)acetaldehyde (109330-01-0)

Guidance literature:

(methoxymethyl)triphenylphosphonium chloride; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.75h; Inert atmosphere;

3-Phenoxybenzaldehyde; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ml3001616

Reference yield: 75.0%

→ 2--(6--methoxynaphthalen--2--yl)acetaldehyde (109330-01-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; Reflux;

Reference yield:

3-hydroxy-benzeneacetic acid, methyl ester (42058-59-3) → 2--(6--methoxynaphthalen--2--yl)acetaldehyde (109330-01-0)

Guidance literature:

Multi-step reaction with 3 steps

1: copper diacetate; pyridine / 1,2-dichloro-ethane / 20 °C / Molecular sieve

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 - 20 °C

3: Dess-Martin periodane / dichloromethane / 8 h / 0 - 20 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; copper diacetate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; 1: |Chan-Lam Coupling;

DOI:10.1021/acs.jmedchem.7b01570

upstream raw materials:

(methoxymethyl)triphenylphosphonium chloride

3-Phenoxybenzaldehyde

2-(3-phenoxyphenyl)ethanol

m-hydroxyphenylacetic acid

Downstream raw materials:

(3-phenoxyphenyl)acetic acid

methyl -1--(3--phenoxyphenyl)cyclopropanecarboxylate

1-(3-phenoxyphenyl)cyclopropanecarboxylic acid

methyl 2-(3-phenoxyphenyl)acetate