4-AMINO-N-(2-HYDROXY-3-PHENOXY-PROPYL)-BENZAMIDE

Base Information

• Chemical Name: 4-AMINO-N-(2-HYDROXY-3-PHENOXY-PROPYL)-BENZAMIDE
• CAS No.: 112169-43-4
• Molecular Formula: C16H18N2O3
• Molecular Weight: 286.32600
• Mol file: 112169-43-4.mol

Synonyms:4-Amino-N-(2-hydroxy-3-phenoxy-propyl)-benzamide;

Chemical Property of 4-AMINO-N-(2-HYDROXY-3-PHENOXY-PROPYL)-BENZAMIDE

Chemical Property:

• PSA: 84.58000
• LogP: 2.41060

Purity/Quality:

98%min ^*data from raw suppliers

4-Amino-N-(2-hydroxy-3-phenoxy-propyl)-benzamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 4-AMINO-N-(2-HYDROXY-3-PHENOXY-PROPYL)-BENZAMIDE

There total 3 articles about 4-AMINO-N-(2-HYDROXY-3-PHENOXY-PROPYL)-BENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(p-Nitrobenzoyl)-3-phenoxy-2-oxypropylamine (112169-42-3) → N-(p-Aminobenzoyl)-3-phenoxy-2-oxypropylamine (112169-43-4)

Guidance literature:

With acetic acid; zinc; In water; at 120 ℃; for 2h;

DOI:10.1007/BF01146187

Reference yield:

1-amino-3-phenoxy-isopropanol (4287-19-8,86809-26-9) → N-(p-Aminobenzoyl)-3-phenoxy-2-oxypropylamine (112169-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / triethylamine / benzene / Ambient temperature

2: 80 percent / acetic acid , Zn / H₂O / 2 h / 120 °C

With acetic acid; triethylamine; zinc; In water; benzene;

DOI:10.1007/BF01146187

Reference yield:

4-nitro-benzoyl chloride (122-04-3) → N-(p-Aminobenzoyl)-3-phenoxy-2-oxypropylamine (112169-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / triethylamine / benzene / Ambient temperature

2: 80 percent / acetic acid , Zn / H₂O / 2 h / 120 °C

With acetic acid; triethylamine; zinc; In water; benzene;

DOI:10.1007/BF01146187

upstream raw materials:

N-(p-Nitrobenzoyl)-3-phenoxy-2-oxypropylamine

1-amino-3-phenoxy-isopropanol

4-nitro-benzoyl chloride

Refernces