N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-L-tyrosine methyl ester

Base Information

Chemical Name:N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-L-tyrosine methyl ester
CAS No.:112196-59-5
Molecular Formula:C16H23NO5
Molecular Weight:309.362
Hs Code.:
DSSTox Substance ID:DTXSID201168538

Synonyms:112196-59-5;SCHEMBL20422634;DTXSID201168538;EN300-23108395;N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-L-tyrosine methyl ester;methyl (2S)-2-{[(tert-butoxy)carbonyl](methyl)amino}-3-(4-hydroxyphenyl)propanoate

Suppliers and Price of N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-L-tyrosine methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-L-tyrosine methyl ester

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:309.15762283
Heavy Atom Count:22
Complexity:383

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N(C)C(CC1=CC=C(C=C1)O)C(=O)OC
Isomeric SMILES:CC(C)(C)OC(=O)N(C)[C@@H](CC1=CC=C(C=C1)O)C(=O)OC

Technology Process of N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-L-tyrosine methyl ester

There total 6 articles about N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-L-tyrosine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

: 24424-99-5
di-tert-butyl dicarbonate

: 70963-39-2
N-methyl-L-tyrosine methyl ester

: 112196-59-5
methyl N-(tert-butoxycarbonyl)-N-methyl-L-tyrosinate

Guidance literature:: In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1248/cpb.43.1325

Reference yield: 82.0%

: 112196-58-4
(S)-methyl-2-((tert-butoxycarbonyl)(methyl)amino)-3-(4-((tert-butyldimethyl-silyl)oxy)phenyl)propanoate

: 112196-59-5
methyl N-(tert-butoxycarbonyl)-N-methyl-L-tyrosinate

Guidance literature:: With acetic acid; In tetrahydrofuran; water; at 25 ℃; for 8h;
DOI:10.1021/jo00238a005

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 112196-59-5
methyl N-(tert-butoxycarbonyl)-N-methyl-L-tyrosinate

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / imidazole / dimethylformamide / 6 h / 25 °C

2: 87 percent / NaH / dimethylformamide / 48 h / 25 °C

3: 82 percent / AcOH / tetrahydrofuran; H₂O / 8 h / 25 °C

With 1H-imidazole; sodium hydride; acetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00238a005