Benzaldehyde, 2,2'-(1,4-piperazinediyl)bis-

Base Information

• Chemical Name: Benzaldehyde, 2,2'-(1,4-piperazinediyl)bis-
• CAS No.: 112253-19-7
• Molecular Formula: C18H18N2O2
• Molecular Weight: 294.353
• DSSTox Substance ID: DTXSID50383890
• Wikidata: Q82175696
• Mol file: 112253-19-7.mol

Synonyms:Benzaldehyde, 2,2'-(1,4-piperazinediyl)bis-;112253-19-7;2-[4-(2-formylphenyl)piperazino]benzaldehyde;AGFKSKNIVHVUDT-UHFFFAOYSA-;DTXSID50383890;MFCD00099861;InChI=1/C18H18N2O2/c21-13-15-5-1-3-7-17(15)19-9-11-20(12-10-19)18-8-4-2-6-16(18)14-22/h1-8,13-14H,9-12H2

Chemical Property of Benzaldehyde, 2,2'-(1,4-piperazinediyl)bis-

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 294.136827821
• Heavy Atom Count: 22
• Complexity: 343

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN(CCN1C2=CC=CC=C2C=O)C3=CC=CC=C3C=O

Technology Process of Benzaldehyde, 2,2'-(1,4-piperazinediyl)bis-

There total 1 articles about Benzaldehyde, 2,2'-(1,4-piperazinediyl)bis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

piperazine (110-85-0) + 2-Fluorobenzaldehyde (446-52-6) → 2,2'-(1,4-Piperazinediyl)bisbenzaldehyde (112253-19-7)

Guidance literature:

piperazine; With potassium carbonate; In N,N-dimethyl-formamide; at 180 ℃; for 1h;

2-Fluorobenzaldehyde; In N,N-dimethyl-formamide; for 48h; Reflux; Inert atmosphere;

DOI:10.1016/j.poly.2009.12.005

Reference yield: 66.0%

1,3-dimethylbarbituric acid (769-42-6) + 2,2'-(1,4-Piperazinediyl)bisbenzaldehyde (112253-19-7) → 5,5'-((piperazine-1,4-diylbis(2,1-phenylene))bis(methaneylylidene))bis(1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione)

Guidance literature:

With 4-methylpiperidin; acetic acid; In ethanol; at 80 ℃;

DOI:10.1002/adsc.202101187

Reference yield: 61.0%

2,2'-(1,4-Piperazinediyl)bisbenzaldehyde (112253-19-7) + malonic acid dimethyl ester (108-59-8) → tetramethyl 2,2'-((piperazine-1,4-diylbis(2,1-phenylene))bis(methaneylylidene))dimalonate

Guidance literature:

With 4-methylpiperidin; acetic acid; In ethanol; at 80 ℃;

DOI:10.1002/adsc.202101187

upstream raw materials:

piperazine

2-Fluorobenzaldehyde