4-Chloropyridine-2,6-diamine

Base Information

• Chemical Name: 4-Chloropyridine-2,6-diamine
• CAS No.: 6309-00-8
• Molecular Formula: C5H6 Cl N3
• Molecular Weight: 143.576
• Hs Code.: 2933399090
• NSC Number: 41776
• DSSTox Substance ID: DTXSID50285426
• Wikidata: Q82020791
• Mol file: 6309-00-8.mol

Synonyms:4-chloropyridine-2,6-diamine;6309-00-8;2,6-Diamino-4-chloropyridine;4-chloro-2,6-diaminopyridine;2,6-Pyridinediamine, 4-chloro-;NSC41776;SCHEMBL3661086;DTXSID50285426;QUCTYZZZALATJO-UHFFFAOYSA-N;NSC-41776;AKOS006292648;AS-59636;CS-0311932;FT-0687931;EN300-174866;A834209;J-515186

Chemical Property of 4-Chloropyridine-2,6-diamine

Chemical Property:

• Melting Point: 102 °C
• Boiling Point: 338.4±37.0 °C(Predicted)
• PKA: 5.13±0.35(Predicted)
• PSA: 64.93000
• Density: 1.447±0.06 g/cm3(Predicted)
• LogP: 2.06180
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 143.0250249
• Heavy Atom Count: 9
• Complexity: 88.2

Purity/Quality:

99%, ^*data from raw suppliers

4-chloropyridine-2,6-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R23/25:Toxic by inhalation and if swallowed.; R37/38:Irritating to respiratory system and skin.; R41:Risks of seri
• Hazard Codes: R23/25:Toxic by inhalation and if swallowed.; R37/38:Irritating to respiratory system and skin.; R41:Risks of seri
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(N=C1N)N)Cl

Technology Process of 4-Chloropyridine-2,6-diamine

There total 3 articles about 4-Chloropyridine-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

→ 4-chloropyridine-2,6-diamine (6309-00-8)

Guidance literature:

Reference yield:

→ 4-chloropyridine-2,6-diamine (6309-00-8)

Guidance literature:

With hydrogenchloride; sodium nitrite; Erwaermen des Reaktionsproduktes mit wss. Essigsaeure;

DOI:10.1021/ja01597a074

Reference yield:

N,N'-(4-chloro-pyridine-2,6-diyl)-bis-carbamic acid diethyl ester (63708-78-1) → 4-chloropyridine-2,6-diamine (6309-00-8)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01597a074

upstream raw materials:

N,N'-(4-chloro-pyridine-2,6-diyl)-bis-carbamic acid diethyl ester

Downstream raw materials:

7-chloro-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine

4-chloropyridine-2,3,6-triamine

4-chloro-3-phenylazo-pyridine-2,6-diyldiamine

Refernces