S-(2-BenzoylaMino-5-Methylphenyl)diMethylthiocarbaMic acid

Base Information

• Chemical Name: S-(2-BenzoylaMino-5-Methylphenyl)diMethylthiocarbaMic acid
• CAS No.: 112308-03-9
• Molecular Formula: C17H18N2O2S
• Molecular Weight: 314.408
• Hs Code.: 2930909090
• Mol file: 112308-03-9.mol

Synonyms:N-benzoyl-S-dimethylcarbamoyl-2-amino-5-dimethylthiophenol;

Chemical Property of S-(2-BenzoylaMino-5-Methylphenyl)diMethylthiocarbaMic acid

Chemical Property:

• PSA: 78.20000
• LogP: 4.40500

Purity/Quality:

S-[2-(BENZOYLAMINO)-5-METHYLPHENYL]DIMETHYL CARBAMOTHIOIC ACID ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-(2-BenzoylaMino-5-Methylphenyl)diMethylthiocarbaMic acid

There total 10 articles about S-(2-BenzoylaMino-5-Methylphenyl)diMethylthiocarbaMic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-benzoyl-2-amino-5-methylthiophenol (112308-08-4) + N,N-Dimethylcarbamoyl chloride (79-44-7) → N-benzoyl-S-dimethylcarbamoyl-2-amino-5-dimethylthiophenol (112308-03-9)

Guidance literature:

With triethylamine; In acetonitrile; standing overnight;

Reference yield: 31.0%

N-p-tolylbenzohydroxamic acid (1503-92-0) + N,N-Dimethylthiocarbamoyl chloride (16420-13-6) → N-(4-methylphenyl)benzamide (582-78-5) + N-benzoyl-S-dimethylcarbamoyl-N-p-tolylthiohydroxylamine (112308-04-0) + N-benzoyl-S-dimethylcarbamoyl-2-amino-5-dimethylthiophenol (112308-03-9)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; water; several days standing;

Reference yield:

S-benzoyl-N-dimethylcarbamoyl-2-amino-5-methylthiophenol (112308-05-1) → N-benzoyl-S-dimethylcarbamoyl-2-amino-5-dimethylthiophenol (112308-03-9)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium hydroxide / ethanol / 3 h / 180 °C / sealed tube

2: 59 percent / triethylamine / diethyl ether / 0.25 h

3: 76 percent / triethylamine / diethyl ether / 1 h / 20 °C

4: 86 percent / potassium hydroxide / methanol / 24 h

5: 65 percent / triethylamine / acetonitrile / standing overnight

With potassium hydroxide; triethylamine; In methanol; diethyl ether; ethanol; acetonitrile;

upstream raw materials:

benzoyl chloride

N-p-tolylbenzohydroxamic acid

N,N-Dimethylthiocarbamoyl chloride

N-benzoyl-2-amino-5-methylthiophenol

Downstream raw materials:

6-methyl-2-phenyl-1,3-benzothiazole

S-benzoyl-2-amino-5-methylthiophenol

S-benzoyl-N-dimethylcarbamoyl-2-amino-5-methylthiophenol

N,S-dibenzoyl-2-amino-5-methylthiophenol