1503-92-0

Upstream product

• 102469-55-6 N,O-dibenzoyl-N-p-tolyl-hydroxylamine 
• 623-10-9 N-(4-methylphenyl)hydroxylamine 
• 98-88-4 benzoyl chloride 
• 99-99-0 1-methyl-4-nitrobenzene 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 100-52-7 benzaldehyde 

Downstream Products

• 135308-29-1 N-(2-Phenylsulfanyl-acetoxy)-N-p-tolyl-benzamide 
• 532-32-1 sodium benzoate 
• 623-10-9 N-(4-methylphenyl)hydroxylamine 
• 65-85-0 benzoic acid 
• 10205-58-0 6-methyl-2-phenyl-1,3-benzothiazole 
• 112308-08-4 N-benzoyl-2-amino-5-methylthiophenol 
• 112308-07-3 S-benzoyl-2-amino-5-methylthiophenol 
• 112308-05-1 S-benzoyl-N-dimethylcarbamoyl-2-amino-5-methylthiophenol 
• 112308-03-9 N-benzoyl-S-dimethylcarbamoyl-2-amino-5-dimethylthiophenol 
• 23451-96-9 2-amino-5-methylthiophenol 
• 135308-44-0 1-Benzoyl-5-methyl-3-phenylsulfanyl-1,3-dihydro-indol-2-one 
• 135308-37-1 (2-Benzoylamino-5-methyl-phenyl)-phenylsulfanyl-acetic acid 
• 131740-40-4 {C₆H₅CON(CH₃C₆H₄)O}{O(O)CCH₂C(O)O}B 
• 131740-31-3 {C₆H₅CON(CH₃C₆H₄)O}{OC₆H₄C(O)O}B 

Relevant academic research and scientific papers

Practical bromination of arylhydroxylamines with SOBr2 towards ortho-bromo-anilides

A facile approach for synthesizing ortho-bromoanilides from readily available aryhydroxylamines and thionyl bromide is demonstrated in this work. Mild reaction conditions and broad scope of substrates ranging from heterocyclic structures to pharmaceutics-potential motifs are used in the reactions of this paper. Efficient bromination of ortho C–H bonds of the aryhydroxylamines has been achieved. Ortho-bromoanilide products were obtained in good to excellent yields, and model scaled-up reactions of this synthetic approach are shown in this work.

Cascade Approach to Highly Functionalized Biaryls by a Nucleophilic Aromatic Substitution with Arylhydroxylamines

A transition-metal free synthesis of highly functionalized 2-hydroxy-2′-amino-1,1′-biaryls from N-arylhydroxylamines has been developed. This operationally simple and readily scalable approach relies on a cascade of reactions that initially generates transient N,O-diarylhydroxylamines, via direct O-arylation, which then undergo rapid [3,3]-sigmatropic rearrangement and subsequent rearomatization to form NOBIN-type products. These structurally diverse functionalized biaryls are obtained under mild conditions in good to excellent isolated yields.

Interrupted fischer-indole intermediates via oxyarylation of alkenyl boronic acids

The oxyarylation of alkenyl boronic acids with N-arylbenzhydroxamic acids has been achieved under both copper-mediated and copper-catalyzed conditions to provide access to interrupted Fischer-indole intermediates. This transformation is believed to proceed through a copper-promoted C-O bond forming event followed by a [3,3] rearrangement. The scope of the method is described and mechanistic experiments are discussed.

N-heterocyclic-carbene-catalyzed one-pot synthesis of hydroxamic esters

The honey pot: The NHC-catalyzed reaction between nitrosobenzenes, aromatic/aliphatic aldehydes, and enals proceeded through an aza-benzoin-type reaction and an internal redox esterification to afford hydroxamic esters in good yields. Copyright