alpha-(2-Hydroxyethyl)-2-methyl-N-(2-phenylethyl)-1,3-dioxolane-2-acetamide

Base Information

• Chemical Name: alpha-(2-Hydroxyethyl)-2-methyl-N-(2-phenylethyl)-1,3-dioxolane-2-acetamide
• CAS No.: 128746-84-9
• Molecular Formula: C₁₆H₂₃NO₄
• Molecular Weight: 293.363
• DSSTox Substance ID: DTXSID00926195

Synonyms:BRN 4753792;128746-84-9;1,3-Dioxolane-2-acetamide, alpha-(2-hydroxyethyl)-2-methyl-N-(2-phenylethyl)-;alpha-(2-Hydroxyethyl)-2-methyl-N-(2-phenylethyl)-1,3-dioxolane-2-acetamide;DTXSID00926195;LS-62497;4-Hydroxy-2-(2-methyl-1,3-dioxolan-2-yl)-N-(2-phenylethyl)butanimidic acid

Chemical Property of alpha-(2-Hydroxyethyl)-2-methyl-N-(2-phenylethyl)-1,3-dioxolane-2-acetamide

Chemical Property:

• Vapor Pressure: 1.48E-11mmHg at 25°C
• Boiling Point: 518°C at 760 mmHg
• Flash Point: 267.1°C
• Density: 1.15g/cm³
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 293.16270821
• Heavy Atom Count: 21
• Complexity: 322

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(OCCO1)C(CCO)C(=O)NCCC2=CC=CC=C2

Technology Process of alpha-(2-Hydroxyethyl)-2-methyl-N-(2-phenylethyl)-1,3-dioxolane-2-acetamide

There total 2 articles about alpha-(2-Hydroxyethyl)-2-methyl-N-(2-phenylethyl)-1,3-dioxolane-2-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-acetyl-2-oxo-4,5-dihydrofuran (517-23-7,594837-91-9,98634-97-0,313643-49-1) → N-(2-phenylethyl)amide of α-(1',1'-ethylenedioxy)-ethyl-γ-hydroxybutyric acid (128746-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / p-toluene sulfonic acid / benzene / Heating

2: toluene / 12 h / Heating

With toluene-4-sulfonic acid; In toluene; benzene;

DOI:10.1007/BF01160965

Reference yield:

2-oxo-3(1',1'-ethylenedioxy) ethyltetrahydrofurane (31536-34-2) + phenethylamine (64-04-0) → N-(2-phenylethyl)amide of α-(1',1'-ethylenedioxy)-ethyl-γ-hydroxybutyric acid (128746-84-9)

Guidance literature:

In toluene; for 12h; Heating;

DOI:10.1007/BF01160965

Reference yield: 26.0%

N-(2-phenylethyl)amide of α-(1',1'-ethylenedioxy)-ethyl-γ-hydroxybutyric acid (128746-84-9) → N-(2-phenylethyl)amide of α-(1,1-ethylenedioxy)-ethyl-γ-chlorobutyric acid (160286-85-1)

Guidance literature:

With pyridine; thionyl chloride; In benzene; for 2h; Ambient temperature;

upstream raw materials:

2-oxo-3(1',1'-ethylenedioxy) ethyltetrahydrofurane

phenethylamine

3-acetyl-2-oxo-4,5-dihydrofuran

Downstream raw materials:

N-(2-phenylethyl)amide of α-(1,1-ethylenedioxy)-ethyl-γ-chlorobutyric acid

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