2-[3-(Benzyloxy)propyl]oxirane

Base Information

• Chemical Name: 2-[3-(Benzyloxy)propyl]oxirane
• CAS No.: 112482-35-6
• Molecular Formula: C12H16O2
• Molecular Weight: 192.258
• European Community (EC) Number: 829-997-8
• Nikkaji Number: J1.105.126J
• Mol file: 112482-35-6.mol

Synonyms:2-[3-(benzyloxy)propyl]oxirane;112482-35-6;2-(3-phenylmethoxypropyl)oxirane;2-(3-(benzyloxy)propyl)oxirane;2-(3-Benzyloxy-propyl)-oxirane;SCHEMBL334897;MFCD22414192;FT-0747858;EN300-179241;Z1504686352

Chemical Property of 2-[3-(Benzyloxy)propyl]oxirane

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 192.115029749
• Heavy Atom Count: 14
• Complexity: 152

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1C(O1)CCCOCC2=CC=CC=C2

Technology Process of 2-[3-(Benzyloxy)propyl]oxirane

There total 5 articles about 2-[3-(Benzyloxy)propyl]oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-benzyloxy-4-pentene (81518-74-3) → 1-(benzyloxy)-4,5-epoxypentane (112482-35-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1021/ol203088g

Reference yield:

n-Pent-4-enyl alcohol (821-09-0) → 1-(benzyloxy)-4,5-epoxypentane (112482-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / NaH / tetrahydrofuran / Heating

2: 74 percent / mCPBA / CH₂Cl₂

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; 1: Condensation / 2: Epoxidation;

DOI:10.1002/1099-0690(200004)2000:7<1219::AID-EJOC1219>3.0.CO;2-P

Reference yield:

n-Pent-4-enyl alcohol (821-09-0) → 1-(benzyloxy)-4,5-epoxypentane (112482-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran

2: MCPBA / CH₂Cl₂

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja9842464

upstream raw materials:

1-benzyloxy-4-pentene

n-Pent-4-enyl alcohol

benzyl chloride

benzyl bromide

Downstream raw materials:

(R)-6-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)hexanal

(3R,4S,6R)-9-(benzyloxy)-6-((tert-butyldimethylsilyl)oxy)-3-methylnon-1-en-4-ol

(3R,4S,6R)-9-(benzyloxy)-6-(4-(methoxybenzyl)oxy)-3-methylnon-1-en-4-ol

(3R,4S,6R)-9-(benzyloxy)-4,6-bis((tert-butyldimethylsilyl)oxy)-3-methylnon-1-ene