4-amino-6-phenyl-1,3,5-triazine-2(5H)-thione

Base Information

• Chemical Name: 4-amino-6-phenyl-1,3,5-triazine-2(5H)-thione
• CAS No.: 30369-74-5
• Molecular Formula: C₉H₈N₄S
• Molecular Weight: 204.255
• Mol file: 30369-74-5.mol

Synonyms:1,3,5-Triazine-2(1H)-thione,4-amino-6-phenyl- (9CI); s-Triazine-2-thiol, 4-amino-6-phenyl- (8CI)

Chemical Property of 4-amino-6-phenyl-1,3,5-triazine-2(5H)-thione

Chemical Property:

• Vapor Pressure: 6.41E-05mmHg at 25°C
• Boiling Point: 344.8°C at 760 mmHg
• Flash Point: 162.3°C
• Density: 1.45g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-amino-6-phenyl-1,3,5-triazine-2(5H)-thione

There total 5 articles about 4-amino-6-phenyl-1,3,5-triazine-2(5H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

2-amino-4-chloro-6-phenyl-1,3,5-triazine (3842-53-3) → 4-amino-6-phenyl-1,3,5-triazine-2-thiol (30369-74-5)

Guidance literature:

With sodiumsulfide nonahydrate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

DOI:10.1021/acs.jmedchem.0c01856

Reference yield:

2,4-dichloro-6-phenyl-1,3,5-triazine (1700-02-3) → 4-amino-6-phenyl-1,3,5-triazine-2-thiol (30369-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia / water; dichloromethane / 8 h / 20 °C

2: sodiumsulfide nonahydrate / N,N-dimethyl-formamide / 3 h / 80 °C

With sodiumsulfide nonahydrate; ammonia; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.0c01856

Reference yield:

phenylmagnesium bromide (100-58-3) → 4-amino-6-phenyl-1,3,5-triazine-2-thiol (30369-74-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 6.5 h / 0 - 20 °C / Inert atmosphere

2: ammonia / water; dichloromethane / 8 h / 20 °C

3: sodiumsulfide nonahydrate / N,N-dimethyl-formamide / 3 h / 80 °C

With sodiumsulfide nonahydrate; ammonia; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1: |Grignard Reaction;

DOI:10.1021/acs.jmedchem.0c01856

upstream raw materials:

N-Cyanoguanidine

2,4-dichloro-6-phenyl-1,3,5-triazine

phenylmagnesium bromide

2-amino-4-chloro-6-phenyl-1,3,5-triazine

Downstream raw materials:

4-amino-6-phenyl-1H-[1,3,5]triazin-2-one