PHENYLMAGNESIUM BROMIDE

Base Information

• Chemical Name: PHENYLMAGNESIUM BROMIDE
• CAS No.: 100-58-3
• Molecular Formula: C6H5BrMg
• Molecular Weight: 181.315
• Hs Code.: 29319090
• Mol file: 100-58-3.mol

Synonyms:Phenylmagnesiumbromide (6CI);Bromomagnesiobenzene;Bromophenylmagnesium;

Chemical Property of PHENYLMAGNESIUM BROMIDE

Chemical Property:

• Appearance/Colour: powder
• Melting Point: 153-154 °C
• Boiling Point: 78.8oC at 760 mmHg
• Flash Point: -11 °C
• PSA: 0.00000
• Density: 1.134 g/mL at 25 °C
• LogP: 2.33240
• Storage Temp.: water-free area
• Sensitive.: Air & Moisture Sensitive
• Solubility.: Miscible with tetrahydrofuran.
• Water Solubility.: reacts

Purity/Quality:

99.9% ^*data from raw suppliers

Phenylmagnesium Bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F+, C, F
• Hazard Codes: F+,C,F
• Statements: 12-14-22-34-19-11-67-40-37
• Safety Statements: 16-26-36/37/39-45-33-29-7/8-6A-43B

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Phenylmagnesium Bromide is a reagent used in the preparation of arylcarbonimidic dichlorides via dichloroiodobenzene-mediated gem-dichlorination of aryl isonitriles. Grignard reagent in greener solvent, 2-methyltetrahydrofuran (2-MeTHF)2-Methyltetrahydrofuran (2-MeTHF): A Biomass-Derived Solvent with Broad Application in Organic Chemistry

Technology Process of PHENYLMAGNESIUM BROMIDE

There total 17 articles about PHENYLMAGNESIUM BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

bromobenzene (108-86-1,52753-63-6) → phenylmagnesium bromide (100-58-3)

Guidance literature:

With magnesium; In tetrahydrofuran; at 40 ℃; for 0.25h; Inert atmosphere; Flow reactor;

DOI:10.1021/acs.oprd.9b00493

Reference yield: 98.0%

→ phenylmagnesium bromide (100-58-3)

Guidance literature:

Reference yield: 92.0%

2-amino-5-chlorobenzonitrile (5922-60-1) → (2-amino-5-chlorophenyl)-phenyl-methane-imine (5606-39-3) + phenylmagnesium bromide (100-58-3)

Guidance literature:

upstream raw materials:

bromobenzene

1,3,5-trisbromobenzene

ethyl 2-cyanoacetate

1,2-dichloro-benzene

Downstream raw materials:

(Z)-7-Phenyl-hept-5-enoic acid

(E)-7-phenylhept-5-enoic acid

[2-[hydroxy(diphenyl)methyl]phenyl]diphenylmethanol

2-Ethyl-2-phenylsulfanylmethyl-butane-1-thiol

Refernces

• 1、 Goldbach, Michel,Danieli, Ernesto,Perlo, Juan,Kaptein, Bernard,Litvinov, Victor M.,Blümich, Bernhard,Casanova, Federico,Duchateau, Alexander L.L.. "Preparation of Grignard reagents from magnesium metal under continuous flow conditions and on-line monitoring by NMR spectroscopy". . p. 122 - 125. Retrieved 2016.
• 2、 Riemer, Nastja,Coswig, Christin,Shipman, Mike,Schmidt, Bernd. "Palladium-Catalyzed Cross-Coupling of Arenediazonium Salts with Organoindium or Organobismuth Reagents". . p. 2427 - 2431. Retrieved 2018.
• 3、 Xu, Hang,Hu, Yu-Kun,Guo, Meng-Bi,Huang, Ai-Su,Su, Xin,Guo, Chun. "Design, synthesis and antifungal activity of novel selenochroman-4-one derivatives". . p. 2455 - 2463. Retrieved 2017.
• 4、 Kano, Taichi,Maruoka, Keiji,Matsumoto, Akira,Sakurai, Shunya,Tsuzuki, Saori. "Ni-Catalyzed C(sp2)-H alkylation ofN-quinolylbenzamides using alkylsilyl peroxides as structurally diverse alkyl sources". supporting information. p. 7942 - 7945. Retrieved 2021/08/17.