N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyridyl)-N',N'-dimethylurea

Base Information

• Chemical Name: N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyridyl)-N',N'-dimethylurea
• CAS No.: 75308-65-5
• Molecular Formula: C₁₈H₃₂N₄O
• Molecular Weight: 320.478
• Mol file: 75308-65-5.mol

Synonyms:L 634366

Chemical Property of N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyridyl)-N',N'-dimethylurea

Chemical Property:

• Vapor Pressure: 9.9E-08mmHg at 25°C
• Boiling Point: 433.9°C at 760 mmHg
• Flash Point: 216.2°C
• PSA: 39.68000
• Density: 1.02g/cm³
• LogP: 3.30520

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyridyl)-N',N'-dimethylurea

There total 5 articles about N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyridyl)-N',N'-dimethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4,6-dimethyl-2-pyridinyl)acetamide (5407-88-5) → N,N-Dimethyl-N'-(2-diisopropylamino-ethyl)-N'-(4-ethyl-<2>pyridyl)-harnstoff (75308-65-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, a) 75 deg C, 2 h, b) 90 deg C, 3 h

2: 6N HCl / 5 h / Heating

3: 1.) n-BuLi / 1.) THF, hexane, -5 deg C, 2.) THF, hexane, 0 deg C, 2 h

With hydrogenchloride; n-butyllithium; sodium hydride;

DOI:10.1021/jm00358a015

Reference yield:

1-chloro-2-diisopropylaminoethane hydrochloride (4261-68-1) → N,N-Dimethyl-N'-(2-diisopropylamino-ethyl)-N'-(4-ethyl-<2>pyridyl)-harnstoff (75308-65-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, a) 75 deg C, 2 h, b) 90 deg C, 3 h

2: 6N HCl / 5 h / Heating

3: 1.) n-BuLi / 1.) THF, hexane, -5 deg C, 2.) THF, hexane, 0 deg C, 2 h

With hydrogenchloride; n-butyllithium; sodium hydride;

DOI:10.1021/jm00358a015

Reference yield:

N-<2-(diisopropylamino)ethyl>-N-(4,6-dimethyl-2-pyridyl)acetamide (84369-57-3) → N,N-Dimethyl-N'-(2-diisopropylamino-ethyl)-N'-(4-ethyl-<2>pyridyl)-harnstoff (75308-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 6N HCl / 5 h / Heating

2: 1.) n-BuLi / 1.) THF, hexane, -5 deg C, 2.) THF, hexane, 0 deg C, 2 h

With hydrogenchloride; n-butyllithium;

DOI:10.1021/jm00358a015

upstream raw materials:

2-<<2-(diisopropylamino)ethyl>amino>-4,6-dimethylpyridine

N,N-Dimethylcarbamoyl chloride

N-(4,6-dimethyl-2-pyridinyl)acetamide

1-chloro-2-diisopropylaminoethane hydrochloride

Refernces

A deuterium isotope effect on the inhibition of gastric secretion by N,N-dimethyl-N'-[2-(diisopropylamino)ethyl]-N'-(4,6-dimethyl-2-pyridyl)ure a. Synthesis of metabolites

10.1021/jm00365a020

The research focuses on the synthesis and biological evaluation of certain compounds. In the first part, it details the synthesis of various cephalosporin derivatives, including benzhydryl 3-chloro-7α-(α-phenylacetamido)-3-cephem-4-carboxylate (16) and benzhydryl 7α-amino-3-chloro-3-cephem-4-carboxylate (12), using reagents such as thionyl chloride, anhydrous pyridine, and phosphorus pentachloride. These compounds were characterized by their melting points, IR spectra, and 1H NMR spectra. In the second part, the research examines the use of isotopic substitution to improve the antisecretory potency of N,N-dimethyl-N'-[2-(diisopropylamino)ethyl]-N'-(4,6-dimethyl-2-pyridyl)urea (1) by replacing the pyridine ring methyl hydrogens with deuterium or fluorine, resulting in the hexadeuterated analogue (12) and hexafluoro analogue (11). The synthesis of metabolites 10a and 10b was also developed, involving the condensation of 1,3-diketones with an appropriately N-substituted amidinoacetate. The key chemicals involved in these processes include ethyl 3-imino-3-[[2-(diisopropylamino)ethyl]amino]propionate (2), 1-(benzyloxy)-2,4-pentanedione (3), and dimethylcarbamoyl chloride, among others. The biological results showed that the deuterated analogue 12 was more potent than the protio form 1 in inhibiting gastric acid secretion, while the hexafluoro analogue 11 was less potent.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 75308-65-5 N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyridyl)-N',N'-dimethylurea

Send

Send

Metric Ton KG G Pound L ML

Send

Send