N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyridyl)-N',N'-dimethylurea

Base Information

• Chemical Name: N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyridyl)-N',N'-dimethylurea
• CAS No.: 75308-65-5
• Molecular Formula: C₁₈H₃₂N₄O
• Molecular Weight: 320.478
• Mol file: 75308-65-5.mol

Synonyms:L 634366

Chemical Property of N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyridyl)-N',N'-dimethylurea

Chemical Property:

• Vapor Pressure: 9.9E-08mmHg at 25°C
• Boiling Point: 433.9°C at 760 mmHg
• Flash Point: 216.2°C
• PSA: 39.68000
• Density: 1.02g/cm³
• LogP: 3.30520

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyridyl)-N',N'-dimethylurea

There total 5 articles about N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyridyl)-N',N'-dimethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4,6-dimethyl-2-pyridinyl)acetamide (5407-88-5) → N,N-Dimethyl-N'-(2-diisopropylamino-ethyl)-N'-(4-ethyl-<2>pyridyl)-harnstoff (75308-65-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, a) 75 deg C, 2 h, b) 90 deg C, 3 h

2: 6N HCl / 5 h / Heating

3: 1.) n-BuLi / 1.) THF, hexane, -5 deg C, 2.) THF, hexane, 0 deg C, 2 h

With hydrogenchloride; n-butyllithium; sodium hydride;

DOI:10.1021/jm00358a015

Reference yield:

1-chloro-2-diisopropylaminoethane hydrochloride (4261-68-1) → N,N-Dimethyl-N'-(2-diisopropylamino-ethyl)-N'-(4-ethyl-<2>pyridyl)-harnstoff (75308-65-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, a) 75 deg C, 2 h, b) 90 deg C, 3 h

2: 6N HCl / 5 h / Heating

3: 1.) n-BuLi / 1.) THF, hexane, -5 deg C, 2.) THF, hexane, 0 deg C, 2 h

With hydrogenchloride; n-butyllithium; sodium hydride;

DOI:10.1021/jm00358a015

Reference yield:

N-<2-(diisopropylamino)ethyl>-N-(4,6-dimethyl-2-pyridyl)acetamide (84369-57-3) → N,N-Dimethyl-N'-(2-diisopropylamino-ethyl)-N'-(4-ethyl-<2>pyridyl)-harnstoff (75308-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 6N HCl / 5 h / Heating

2: 1.) n-BuLi / 1.) THF, hexane, -5 deg C, 2.) THF, hexane, 0 deg C, 2 h

With hydrogenchloride; n-butyllithium;

DOI:10.1021/jm00358a015

upstream raw materials:

2-<<2-(diisopropylamino)ethyl>amino>-4,6-dimethylpyridine

N,N-Dimethylcarbamoyl chloride

N-(4,6-dimethyl-2-pyridinyl)acetamide

1-chloro-2-diisopropylaminoethane hydrochloride

Refernces