2-Pyridinepropanoic acid, b-phenyl-

Base Information

• Chemical Name: 2-Pyridinepropanoic acid, b-phenyl-
• CAS No.: 112638-79-6
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.263
• Mol file: 112638-79-6.mol

Synonyms:

Chemical Property of 2-Pyridinepropanoic acid, b-phenyl-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pyridinepropanoic acid, b-phenyl-

There total 4 articles about 2-Pyridinepropanoic acid, b-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(+/-)-3-phenyl-3-(pyridin-2-yl)propionic acid ethyl ester (76132-63-3,85404-31-5,205450-50-6) → 3-phenyl-3-(pyridin-2-yl)propanoic acid (112638-79-6,205450-53-9,205450-54-0)

Guidance literature:

With lithium hydroxide; In 1,2-dimethoxyethane; for 2h; Ambient temperature;

DOI:10.1021/jm970397q

Reference yield:

→ 3-phenyl-3-(pyridin-2-yl)propanoic acid (112638-79-6,205450-53-9,205450-54-0)

Guidance literature:

With potassium hydroxide; isopropyl alcohol;

DOI:10.1021/ja01108a058

Reference yield:

2-bromo-pyridine (109-04-6) → 3-phenyl-3-(pyridin-2-yl)propanoic acid (112638-79-6,205450-53-9,205450-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi, 2.) CuBr(CH₃)2S

2: 99 percent / LiOH / 1,2-dimethoxy-ethane / 2 h / Ambient temperature

With lithium hydroxide; n-butyllithium; copper(I) bromide dimethylsulfide complex; In 1,2-dimethoxyethane;

DOI:10.1021/jm970397q

upstream raw materials:

(+/-)-3-phenyl-3-(pyridin-2-yl)propionic acid ethyl ester

2-bromo-pyridine

ethyl cinnamate

Downstream raw materials:

2-[2-(3-Isopropylidene-5,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)-1-phenyl-ethyl]-pyridine

3-Phenyl-3-(2-pyridyl)propionitrile

3-phenyl-3-(2-pyridyl)propionamide