2-Pyridinepropanenitrile, b-phenyl-

Base Information

• Chemical Name: 2-Pyridinepropanenitrile, b-phenyl-
• CAS No.: 76132-65-5
• Molecular Formula: C14H12N2
• Molecular Weight: 208.263
• Mol file: 76132-65-5.mol

Synonyms:

Chemical Property of 2-Pyridinepropanenitrile, b-phenyl-

Chemical Property:

• PSA: 36.68000
• LogP: 3.12718

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinepropanenitrile, b-phenyl-

There total 8 articles about 2-Pyridinepropanenitrile, b-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-phenyl-3-(2-pyridyl)propionamide (112638-75-2) → 3-Phenyl-3-(2-pyridyl)propionitrile (76132-65-5)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; for 48h; Ambient temperature;

DOI:10.1248/cpb.41.507

Reference yield: 65.0%

(Z,E)-3-Phenyl-3-(2-pyridyl)acrylonitrile (114021-49-7) → 3-Phenyl-3-(2-pyridyl)propionitrile (76132-65-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 8h; Heating;

DOI:10.1248/cpb.28.1394

Reference yield:

benzyl chloride (100-44-7) → 3-Phenyl-3-(2-pyridyl)propionitrile (76132-65-5)

Guidance literature:

Multi-step reaction with 4 steps

1: manganese; trifluoroacetic acid; cobalt(II) bromide / acetonitrile / 40 °C

2: tert.-butylhydroperoxide; iodine; pyridine / neat (no solvent) / 80 °C

3: sodium hydride / tetrahydrofuran / 20 °C

4: sodium tetrahydroborate / isopropyl alcohol / 80 °C

With pyridine; tert.-butylhydroperoxide; manganese; sodium tetrahydroborate; iodine; sodium hydride; trifluoroacetic acid; cobalt(II) bromide; In tetrahydrofuran; isopropyl alcohol; acetonitrile;

DOI:10.1021/acscatal.8b00021

upstream raw materials:

(Z,E)-3-Phenyl-3-(2-pyridyl)acrylonitrile

3-phenyl-3-(2-pyridyl)propionamide

3-phenyl-3-(pyridin-2-yl)propanoic acid

phenyl(pyridin-2-yl)methanone

Downstream raw materials:

2-[2-(3-Isopropylidene-5,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)-1-phenyl-ethyl]-pyridine

pheniramine

midaglizole