N-(P-TOLUENESULFONYL)-D,L-METHIONINE

Base Information

• Chemical Name: N-(P-TOLUENESULFONYL)-D,L-METHIONINE
• CAS No.: 4703-33-7
• Molecular Formula: C12H17 N O4 S2
• Molecular Weight: 303.40
• Mol file: 4703-33-7.mol

Synonyms:DL-Methionine,N-[(4-methylphenyl)sulfonyl]-;Methionine, N-(p-tolylsulfonyl)-, DL- (8CI);N-(p-Tolylsulfonyl)-DL-methionine;N-Tosyl-DL-methionine;N-p-Toluenesulfonyl-DL-methionine;NSC 88476;

Chemical Property of N-(P-TOLUENESULFONYL)-D,L-METHIONINE

Chemical Property:

• Appearance/Colour: off-white to slightly beige crystalline powder
• Vapor Pressure: 2.96E-11mmHg at 25°C
• Melting Point: 105-108 °C
• Refractive Index: 1.6280 (estimate)
• Boiling Point: 510.7 °C at 760 mmHg
• Flash Point: 262.7 °C
• PSA: 117.15000
• Density: 1.311 g/cm³
• LogP: 2.95130

Purity/Quality:

99.5% ^*data from raw suppliers

2-(4-Methylbenzenesulfonamido)-4-(methylsulfanyl)butanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(P-TOLUENESULFONYL)-D,L-METHIONINE

There total 1 articles about N-(P-TOLUENESULFONYL)-D,L-METHIONINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.3%

p-toluenesulfonyl chloride (98-59-9) + DL-methionine (59-51-8,26062-47-5,58576-49-1) → 2-{([(4-methylphenyl)sulphonyl])amino}-4-(methylthio)butanoic acid (4703-33-7)

Guidance literature:

DL-methionine; With sodium carbonate; In water; at -5 ℃; Green chemistry;

p-toluenesulfonyl chloride; In water; at -5 - 20 ℃; for 5h; Green chemistry;

With hydrogenchloride; In water; at 20 ℃; for 12h; Green chemistry;

DOI:10.26452/ijrps.v11i4.3157

Reference yield: 63.0%

2-{([(4-methylphenyl)sulphonyl])amino}-4-(methylthio)butanoic acid (4703-33-7) + (E)-methyl cinnamyl carbonate (87802-71-9,85217-69-2) → cinnamyl tosylmethioninate

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium methylate; diphenyl-(6-methyl-pyridin-2-yl)phosphine; In ethyl acetate; at 25 ℃; for 20h; chemoselective reaction; Glovebox; Inert atmosphere;

DOI:10.1016/j.cclet.2022.02.029

Reference yield:

C36H38N4O4 + 2-{([(4-methylphenyl)sulphonyl])amino}-4-(methylthio)butanoic acid (4703-33-7) → C36H38N4O4*C12H17NO4S2 + C36H38N4O4*C12H17NO4S2

Guidance literature:

In chloroform-d1; at 20 ℃;

DOI:10.1039/c6ob02578a

upstream raw materials:

p-toluenesulfonyl chloride

DL-methionine

Refernces