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Base Information Edit
  • Chemical Name:DL-Methionine
  • CAS No.:59-51-8
  • Deprecated CAS:1105707-18-3,192948-75-7
  • Molecular Formula:C5H11NO2S
  • Molecular Weight:149.214
  • Hs Code.:2930.40
  • European Community (EC) Number:200-432-1
  • ICSC Number:0919
  • NSC Number:522406,118113,45689,22946,9241
  • UNII:73JWT2K6T3
  • DSSTox Substance ID:DTXSID9020821
  • Nikkaji Number:J1.286F
  • Wikipedia:Methionine
  • Wikidata:Q180341
  • NCI Thesaurus Code:C84131
  • RXCUI:6837
  • Metabolomics Workbench ID:46301
  • ChEMBL ID:CHEMBL274119
  • Mol file:59-51-8.mol

Synonyms:Methilonin;Methionine, amorphous;Methionine, DL-;Hmet;Meonine;DL-Methioninum;Pedameth;2-amino-4-(methylsulfanyl)butanoic acid;(2S)-2-azaniumyl-4-methylsulfanyl-butanoate;(2R)-2-azaniumyl-4-methylsulfanyl-butanoate;Urimeth;Metione;2-amino-4-(methylthio)butanoic acid;Cynaron;Dyprin;Lobamine;(+-)-Methionine;Racemethionine [USAN];Neston;alpha-Amino-gamma-(methylthio)butyric acid;DL-2-Amino-4-(methylthio)-butyric acid;Acimetion;Banthionine;alpha-amino-gamma-methylmercaptobutyric acid;DL-2-Amino-4-(methylthio)butanoic acid;DL-2-Amino-4-methylthiobutyric acid;H-DL-Met-OH;Racemethionine;

Suppliers and Price of DL-Methionine
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
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Total 344 raw suppliers
Chemical Property of DL-Methionine Edit
Chemical Property:
  • Appearance/Colour:white crystalline powder with a faint odor 
  • Melting Point:284 °C (dec.)(lit.) 
  • Boiling Point:306.9 °C at 760 mmHg 
  • Flash Point:139.4 °C 
  • PSA:88.62000 
  • Density:1.206 g/cm3 
  • LogP:0.85170 
  • Solubility.:Sparingly soluble in water, very slightly soluble in alcohol. It dissolves in dilute acids and in dilute solutions of the alkali hydroxides 
  • Water Solubility.:2.9 g/100 mL (20℃) 
  • XLogP3:-1.9
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:4
  • Rotatable Bond Count:4
  • Exact Mass:149.05104977
  • Heavy Atom Count:9
  • Complexity:97

99%min *data from raw suppliers

Safty Information:
  • Pictogram(s): IrritantXi 
  • Hazard Codes:Xi 
  • Safety Statements: S24/25:; 
MSDS Files:

SDS file from LookChem

  • Chemical Classes:Biological Agents -> Amino Acids and Derivatives
  • Canonical SMILES:CSCCC(C(=O)O)N
  • Recent ClinicalTrials:Methionine PET/CT Studies In Patients With Cancer
  • Recent NIPH Clinical Trials:Molecular Imaging using amino-acid PET tracer: Clinical research for diagnostic and therapeutic evaluation with amino acid PET tracer for multiple myeloma
  • Definition and Composition Racemethionine, also known as DL-methionine, is an amino acid used to meet animals' requirements in sulfur amino acids such as methionine and cysteine. It is composed of two enantiomers: D-methionine and L-methionine.
  • Functionality and Importance Methionine is considered the first limiting amino acid for broilers fed a practical corn-soybean meal diet, highlighting the significance of racemethionine supplementation in animal nutrition.
  • Formulation in Feed Racemethionine is commonly utilized in animal feed formulations. It may be included as dry DL-methionine (DL-Met; 99% pure) or as a liquid DL-methionine hydroxy analog-free acid (MHA-FA, containing 88% of the active substance).
  • Interrelationship with Protein and Lipotropic Action Methionine, including racemethionine, plays a role as a lipotropic agent, aiding in the production of lean carcasses. Its interrelationship with protein involves balancing protein synthesis and acting as a methyl donor, influencing choline, betaine, folic acid, and vitamin B12 metabolism.
  • Chirality and Biological Activity While all amino acids occurring in animal tissues are L-isomers, methionine presents an exception as birds can utilize both D- and L-forms or a DL-racemic mixture.
Technology Process of DL-Methionine

There total 84 articles about DL-Methionine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
2-hydroxy-4-(methylthio)butyronitrile; With ammonia; In water; at 50 ℃; for 0.5h; Sealed tube;
With cerium(IV) oxide; In water; at 75 ℃; for 2h; Reagent/catalyst; Temperature; Sealed tube;
Guidance literature:
With zirconium containing nickel oxide; In water; at 130 ℃; for 1h; Reagent/catalyst; Temperature;
Guidance literature:
5-[2-(methylthio)ethyl]imidazolidine-2,4-dione; With water; potassium carbonate; at 120 - 160 ℃; Sonication;
at 80 - 120 ℃; Reagent/catalyst; Sonication;
Refernces Edit
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