1-benzyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

Base Information

• Chemical Name: 1-benzyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
• CAS No.: 112758-88-0
• Molecular Formula: C14H16N2
• Molecular Weight: 212.29000
• Mol file: 112758-88-0.mol

Synonyms:1-benzyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine;1-Benzyl-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine;

Chemical Property of 1-benzyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

Chemical Property:

• PSA: 16.96000
• LogP: 2.70390

Purity/Quality:

98%min ^*data from raw suppliers

1-Benzyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

There total 7 articles about 1-benzyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-Benzyl-3,4-dihydropyrrolo<1,2-a>pyrazine (111609-52-0) → 1-Benzyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine (112758-88-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Heating;

DOI:10.1007/BF01145551

Reference yield:

1,2,3,4-Tetrahydropyrrolo<1,2-a>pyrazine (71257-38-0) → 1-Benzyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine (112758-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Raney nickel / xylene / Heating

2: 1.) Mg / 1.) ether, 2.) reflux

With magnesium; nickel; In xylene;

DOI:10.1007/BF01145551

Reference yield:

C14H16N2O → 1-Benzyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine (112758-88-0)

Guidance literature:

C₁₄H₁₆N₂O; With trichlorophosphate; In toluene; at 20 ℃; for 2h; Inert atmosphere; Reflux;

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201509256

upstream raw materials:

benzyl chloride

3,4-dihydropyrrolo[1,2-a]-pyrazine

1-Benzyl-3,4-dihydropyrrolo<1,2-a>pyrazine

1,2,3,4-Tetrahydropyrrolo<1,2-a>pyrazine