71257-38-0

Usage

Uses

Used in Pharmaceutical Industry:
Pyrrolo[1,2-a]pyrazine, 1,2,3,4-tetrahydro(9CI) is used as a key building block in the synthesis of various pharmaceuticals. Its potential biological activities and ongoing research for new drug development highlight its importance in creating innovative and effective medications.
Used in Agrochemical Industry:
In the agrochemical sector, Pyrrolo[1,2-a]pyrazine, 1,2,3,4-tetrahydro(9CI) serves as a crucial component in the development of new agrochemicals. Its role in creating effective and environmentally friendly solutions for pest control and crop protection is significant.
Used in Fragrance and Flavor Industry:
Pyrrolo[1,2-a]pyrazine, 1,2,3,4-tetrahydro(9CI) is utilized in the fragrance and flavor industry due to its interesting odor properties. It contributes to the creation of unique and appealing scents and tastes in various consumer products, enhancing the sensory experience for users.

InChI:InChI=1/C7H10N2/c1-2-7-6-8-3-5-9(7)4-1/h1-2,4,8H,3,5-6H2

Upstream product

• 71257-37-9 3,4-dihydropyrrolo[1,2-a]-pyrazine 
• 29709-35-1 1-(2-aminoethyl)pyrrole 
• 50-00-0 formaldehyd 

Downstream Products

• 274-45-3 7-azaindolizine 
• 71257-37-9 3,4-dihydropyrrolo[1,2-a]-pyrazine 
• 1416220-64-8 2,2-dimethyl-1-(7-(phenylethynyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)propan-1-one 
• 1174068-78-0 3,4-Dihydro-1H-pyrrolo[1,2-a]pyrazine-2-carboxylic acid tert-butyl ester 
• 165117-99-7 2-acetyl-1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine 
• 165118-06-9 2-benzoyl-1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine 
• 112758-88-0 1-Benzyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine 
• 112758-89-1 1-Phenyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine 
• 112758-87-9 1-Cyclohexyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine 

Relevant academic research and scientific papers

Compound as potassium channel modulator

The invention relates to a compound as a potassium channel modulator, which is a compound of a formula (I) or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof is effective for curing and preventing diseases and symptoms influenced by the activity of potassium ion channels.

Design, synthesis and evaluation of novel N-phenylbutanamide derivatives as KCNQ openers for the treatment of epilepsy

KCNQ (Kv7) has emerged as a validated target for the development of novel anti-epileptic drugs. In this paper, a series of novel N-phenylbutanamide derivatives were designed, synthesized and evaluated as KCNQ openers for the treatment of epilepsy. These compounds were evaluated for their KCNQ opening activity in vitro and in vivo. Several compounds were found to be potent KCNQ openers. Compound 1 with favorable in vitro activity was submitted to evaluation in vivo. Results showed that compound 1 owned significant anti-convulsant activity with no adverse effects. It was also found to posses favorable pharmacokinetic profiles in rat. This research may provide novel potent compounds for the discovery of KCNQ openers in treating epilepsy.

PHTHALAZINONE KETONE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL USE THEREOF

A phthalazinone ketone derivative as represented by formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, a use thereof as a poly (ADP-ribose) polymerase (PARP) inhibitor, and a cancer treatment method thereof.

PHTHALAZINONE KETONE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL USE THEREOF

A phthalazinone ketone derivative as represented by formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, a use thereof as a poly (ADP-ribose) polymerase (PARP) inhibitor, and a cancer treatment method thereof are described.

Substituted Sulfonamide Compounds

Substituted sulfonamide compounds corresponding to the formula I wherein m, n, p, Q, R1, R2, R3, R4, X, Y and Z have the respective meanings defined herein, pharmaceutical compositions containing such compounds, a process for their preparation, and the use of such compounds for the treatment and/or inhibition of pain and other conditions mediated by bradykinin receptor 1 (B1R) and/or bradykinin receptor 2 (B2R).

SUBSTITUTED SULFONAMIDE DERIVATIVES

The invention relates to substituted sulfonamide derivatives of the general formula (I'); processes for their preparation, medicaments containing these compounds, and the use of substituted sulfonamide derivatives for the preparation of medicaments

SUBSTITUTED SULFONAMIDE COMPOUNDS

Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.

1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives

1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives having the formula (Formula I) STR1 and therapeutically acceptable acid addition salts thereof (Formula I.HX), wherein: R1 =hydrogen or acyl groups; and R2 =hydrogen or substituted